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PF 10040
platelet activating factor antagonist
Also Known As:
1-(3,4-dimethoxyphenylethyl)-6-methyl-3,4-dihydroisoquinoline; PF-10040; PF10040
Networked:
2
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
PF 10040: 2
Related Diseases
1.
Gastritis
06/01/1993 - "
Protective effects of PF-10040 in experimental NSAID-gastritis: role of leukocytes, leukotrienes and PAF.
"
06/01/1993 - "
The effects and mechanism of action of PF-10040, a quinoline derivative, were examined in an experimental model of NSAID-gastritis.
"
2.
Respiratory Hypersensitivity
01/01/1994 - "
5. We provide further evidence that pulmonary eosinophil infiltration and the development of airway hyperresponsiveness are not causally related events as the lower dose of PF 10040 (5 mg) significantly inhibited PAF-induced airway hyperresponsiveness yet was without effect on the eosinophil influx.
"
01/01/1994 - "
4. We suggest from the results of the present study that PF 10040 does not exert an inhibitory effect on PAF-induced airway responses solely via antagonism of the PAF receptor located on platelets, as PF 10040 significantly inhibited PAF-induced airway hyperresponsiveness in the absence of an effect on the acute bronchospasm induced by PAF.
"
3.
Bronchial Spasm
01/01/1994 - "
4. We suggest from the results of the present study that PF 10040 does not exert an inhibitory effect on PAF-induced airway responses solely via antagonism of the PAF receptor located on platelets, as PF 10040 significantly inhibited PAF-induced airway hyperresponsiveness in the absence of an effect on the acute bronchospasm induced by PAF.
"
Related Drugs and Biologics
1.
Leukotrienes
2.
Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
3.
quinoline