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aprosulate
synthetic sulfated bis(lactobionic acid)amide
Also Known As:
LW 10082; LW-10082; D-Gluconamide, N,N'-1,3-propanediylbis(4-O-(2,3,4,6-tetra-O-sulfo-beta-D-galactopyranosyl))-, 2,2',3,3',5,5',6,6'-octakis(hydrogen sulfate), hexadecasodium salt
Networked:
5
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Polysaccharides: 15383
Oligosaccharides: 3566
Disaccharides: 990
aprosulate: 5
Sugars: 11126
Disaccharides: 990
aprosulate: 5
Related Diseases
1.
Body Weight (Weight, Body)
01/01/1991 - "
5. In subchronic toxicologic studies in rats, LW 10082 was well tolerated up to a dosage of 100 mg/kg body weight.
"
10/15/1993 - "
Twelve healthy male volunteers received subcutaneous injections of placebo on the first day followed by ascending doses of aprosulate in the range of 0.25 mg/kg to 2.0 mg/kg body weight on alternate days.
"
07/01/1999 - "
Eighteen healthy volunteers aged 21 to 30 years received two single subcutaneous doses of aprosulate (0.5 mg/kg body weight; 1.0 mg/kg body weight), or unfractionated heparin (Calciparin 7,500 IU).
"
2.
Venous Thrombosis (Deep-Vein Thrombosis)
07/01/1999 - "
Further clinical trials will have to establish whether aprosulate is an effective drug for the prophylaxis of deep venous thrombosis.
"
3.
Thrombosis (Thrombus)
01/01/1996 - "
Aprosulate (1-30 mg/kg, i.v.) inhibited thrombus formation in a dose-dependent manner.
"
05/01/1996 - "
Our results suggest that combinations of LW 10082 with LMWH may provide a new approach to more effective prophylaxis and treatment of venous or arterial thrombosis.
"
05/01/1996 - "
The minimal effective dose of LW 10082 which significantly inhibited thrombus formation was 5 mg/kg. The antithrombotic effect of Aspisol has been investigated after its oral application at doses of 1.5 and 10 mg/kg 2 h before studying the antithrombotic effect.
"
05/01/1996 - "
Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model.
"
05/01/1996 - "
We investigated the comparative antithrombotic properties of LW 10082, acetylasalicylic acid (Aspisol), low molecular weight heparin (LMWH, CY 216) and sodium heparin using laser-induced thrombosis model.
"
Related Drugs and Biologics
1.
Heparin (Liquaemin)
2.
Nadroparin (Nadroparin Calcium)
3.
Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
4.
Fibrinolytic Agents (Antithrombotic Agents)
5.
Acids
6.
acetylsalicylic acid lysinate
7.
calcium heparin (Calciparine)
8.
lactobionic acid (lactobionate)
Related Therapies and Procedures
1.
Lasers (Laser)
2.
Subcutaneous Injections