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2- methyl- 6,7- dihydroxy- 1,2,3,4- tetrahydroisoquinoline
present in parkinsonian & normal human brains; RN given refers to parent cpd; structure given in first source
Also Known As:
2-MDTIQ; 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide; 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; N-methylnorsalsolinol; NMNSAL
Networked:
3
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
Tetrahydroisoquinolines: 44
2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline: 3
Related Diseases
1.
Parkinson Disease (Parkinson's Disease)
12/01/1997 - "
2-MDTIQ may represent an essential factor in the degenerative process of Parkinson's disease.
"
12/01/1997 - "
Thus, 2-MDTIQ is suggested not only to represent an endogenous marker of Parkinson's disease, but also to support changes in the transmitter synthesis of dopaminergic neurons.
"
12/01/1997 - "
Previous studies of the dopamine metabolism in Parkinson's disease have demonstrated an increased dopamine turnover in the presence of 2-MDTIQ.
"
08/01/1995 - "
In order to study the relationship between presence of 2-MDTIQ and dopamine metabolism, we examined 3-O-methyl-dopa (MDOPA) and homovanillic acid (HVA) levels in CSF of 15 normal control subjects and 34 patients with Parkinson's disease (PD).
"
2.
Parkinsonian Disorders (Parkinsonism)
03/05/1993 - "
N-Methylsalsolinol and N-methylnorsalsolinol, which are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces parkinsonism in humans, may be synthesized from N-methyldopamine by the Pictet-Spengler condensation reaction as an alternative metabolic pathway.
"
Related Drugs and Biologics
1.
Dopamine (Intropin)
2.
Homovanillic Acid
3.
3-methoxytyrosine
4.
1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
5.
Deoxyepinephrine
6.
salsoline