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hydroxyethyl starch-deferoxamine conjugate
improves the recovery of postischemic function in the reversibly-injured stunned myocardium
Also Known As:
HES-DFO; deferoxamine-hydroxyethyl starch conjugate
Networked:
13
relevant articles (
3
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Hydroxylamines: 16
Hydroxamic Acids: 239
Deferoxamine: 2842
hydroxyethyl starch-deferoxamine conjugate: 13
Carboxylic Acids: 973
Hydroxy Acids: 94
Hydroxamic Acids: 239
Deferoxamine: 2842
hydroxyethyl starch-deferoxamine conjugate: 13
Carbohydrates: 22023
Polysaccharides: 15383
Glucans: 1624
Starch: 3882
Hydroxyethyl Starch Derivatives: 409
hydroxyethyl starch-deferoxamine conjugate: 13
Dietary Carbohydrates: 706
Starch: 3882
Hydroxyethyl Starch Derivatives: 409
hydroxyethyl starch-deferoxamine conjugate: 13
Experts
1.
Pizanis, A
: 1 article (08/2000)
2.
Rose, S
: 1 article (08/2000)
3.
Silomon, M
: 1 article (08/2000)
4.
Autenrieth, I B
: 1 article (05/2000)
5.
Schubert, S
: 1 article (05/2000)
Related Diseases
1.
Septic Shock (Toxic Shock Syndrome)
05/01/2000 - "
Thus, due to the delayed in vivo effect HES-DFO failed to trigger Yersinia-induced septic shock, which accounts for early mortality in DFO-associated septicemia.
"
12/01/1995 - "
The protective effects of hydroxyethyl starch-conjugated deferoxamine (HES-DFO), a macromolecular iron chelator, on the initial pathophysiological cascade in septic shock were evaluated following cecal ligation puncture (CLP) in rats.
"
2.
Myocardial Stunning (Stunned Myocardium)
01/01/1991 - "
Thus, high-molecular-weight HES-DFO is effective in enhancing the recovery of regional wall motion in stunned myocardium.
"
01/01/1991 - "
The effect of hydroxyethyl starch-conjugated deferoxamine (HES-DFO) on the recovery of regional myocardial function after 15 min of coronary artery occlusion followed by 3 h of reperfusion of the left anterior descending coronary artery (stunned myocardium) was investigated in anesthetized dogs.
"
3.
Type 1 Diabetes Mellitus (Autoimmune Diabetes)
04/01/1994 - "
Administration of HES-DFO further significantly decreased the incidence of IDDM to 31% as compared with the lymphopenic unmanipulated rats (p < 0.01).
"
4.
Hemorrhagic Shock
02/01/1995 - "
To determine the effects of a hydroxyethyl starch-deferoxamine conjugate on hepatic microcirculation in an isobaric, anesthetized rat model of hemorrhagic shock and asanguineous resuscitation.
"
08/01/2000 - "
This study investigated whether hepatocyte Ca2+ dysregulation after hemorrhagic shock and resuscitation could be modulated by the iron chelator hydroxyethyl starch-conjugated deferoxamine (HES-DFO).
"
5.
Neoplasms (Cancer)
09/01/1995 - "
It was shown that while neither HES-DFO alone nor C2 alone produced consistent, significant inhibition of tumor growth, the combination of HES-DFO and C2 produced virtually complete inhibition of initial tumor outgrowth.
"
11/01/1996 - "
In clinical studies, sEPO levels rose in adult volunteers treated with DFO coupled to hydroxyethyl starch (HES-DFO) and in patients with advanced malignancy treated with anti-Tf receptor antibody 42/6, in a time- and dose-dependent manner.
"
09/01/1995 - "
A high molecular weight conjugate of deferoxamine, known as hydroxyethyl starch (HES) DFO or HES-DFO, was tested in conjunction with C2, a well-defined rat antimouse transferrin receptor mAb, against the 38C13 tumor in C3H/HeN mice.
"
Related Drugs and Biologics
1.
Starch (Cornstarch)
2.
Iron
3.
Deferoxamine (Desferal)
4.
Chelating Agents
5.
Fluorescein (Funduscein)
6.
Thiobarbituric Acid Reactive Substances
7.
Reactive Oxygen Species (Oxygen Radicals)
8.
Retinaldehyde (Retinal)
9.
Transferrin Receptors (Transferrin Receptor)
10.
Membrane Lipids
Related Therapies and Procedures
1.
Ligation
2.
Punctures
3.
Resuscitation
4.
Therapeutics