HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

CI 966

GABA uptake blocker; RN from Toxlit

Also Known As:

1-(2-(bis(4-(trifluoromethyl)phenyl)methox)ethyl)-1,2,5,6-tetrahydro-3-pyrdinecarboxylic acid; CI-966; CI-966 free base

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - CI 966: 3

Experts

1.	Nguyen, Ngan: 1 article (08/2021)
2.	Patel, Kruti: 1 article (08/2021)
3.	Uhelski, Anna Carson: 1 article (08/2021)
4.	Waters, Bradford: 1 article (08/2021)
5.	Weir, Alva: 1 article (08/2021)
6.	Green, A R: 1 article (07/2000)
7.	Hainsworth, A H: 1 article (07/2000)
8.	Jackson, D M: 1 article (07/2000)

Related Diseases

1.	Liver Diseases (Liver Disease) 08/01/2021 - "In a multivariate analysis accounting for severity of liver disease, treated patients had an improved 5-year OS rate, median 1338 days (95% CI, 966-3202) when compared with untreated patients whose median OS was 452 days (95% CI, 242-853) (P = .0005). "
2.	Stroke (Strokes) 09/01/1995 - "CI-966 reduced the extent of stroke injury as assessed by locomotor activity and measurement of hippocampal CA1 pyramidal cell injury. " 09/01/1995 - "3. The GABA transport inhibitor CI-966 (10 mg/kg i.p.) was tested for cerebroprotective activity in a gerbil stroke model. " 07/10/2000 - "The GABA uptake inhibitor CI-966, the GABA(A) agonist muscimol and the GABA(A)mimetic clomethiazole have all been shown to be neuroprotective in animal models of stroke when given after the ischaemic insult. "
3.	Ischemia 09/01/1995 - "4. It is proposed that enhancement of extracellular GABA levels during ischemia accounts for the cerebroprotective actions of CI-966." 09/01/1995 - "CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil."

Related Drugs and Biologics

1.	GABA Uptake Inhibitors
2.	gamma-Aminobutyric Acid (GABA)
3.	Muscimol
4.	Chlormethiazole (Clomethiazole)