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SDZ 33-243
cpd is non-immunosuppressive
Also Known As:
B3-243; O-acetyl C(9) cyclosporin A; OACsA; SDZ-33-243; cyclosporine A acetate
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
Cyclosporins: 35
SDZ 33-243: 3
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Cyclic Peptides: 530
Cyclosporins: 35
SDZ 33-243: 3
Related Diseases
1.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
09/01/1992 - "
The cytotoxic activity of cyclosporin A (CsA) and the three non-immuno-suppressive CsA analogues B3-243, WO-039 and B3-665 were studied in tumor cell lines representing both classical and atypical forms of multidrug resistance (MDR): T-ALL GM3639 L100 cells selected for vincristine (vcr) resistance and displaying characteristics of classical MDR, including P-glycoprotein (pgp) expression and increased drug efflux which can be inhibited by pgp blockers (e.g.
"
2.
Lung Neoplasms (Lung Cancer)
09/01/1988 - "
The non-immunosuppressive analogue, B3-243, is at least as effective as CsA as an antiproliferative in human lung cancer cell lines.
"
3.
Hypersensitivity (Allergy)
09/01/1992 - "
Compared to LO cells, L100 cells showed a marked hypersensitivity to CsA > B3-243 > WO-039 with B3-665 being inactive.
"
4.
Bone Resorption
03/01/1991 - "
The effects of cyclosporine A (CsA) and one of its immunologically inactive structural analogues, cyclosporine A acetate (CsA-A) on lipopolysaccharide (LPS)-, interleukin-1 (IL-1)-, 1,25 dihydroxyvitamin D3 (1,25 D3)- and parathyroid hormone (PTH)-stimulated bone resorption were tested in mouse calvaria cultures.
"
Related Drugs and Biologics
1.
Cyclosporine (Ciclosporin)
2.
Member 1 Subfamily B ATP Binding Cassette Transporter
3.
Vincristine (Oncovin)
4.
Parathyroid Hormone (Parathormone)
5.
Lipopolysaccharides
6.
Interleukin-1 (Interleukin 1)
7.
Calcitriol (Calcijex)