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AA 863
Also Known As:
AA-863
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Quinones: 434
Benzoquinones: 25
AA 863: 1
Related Diseases
1.
Glioma (Gliomas)
06/01/1990 - "
The results of the monolayer studies showed potent and dose dependent inhibitory effects on the proliferation of glioma cells (IC50/one week treatment/of AA-863: 9.0 microM, IC50 of U-60,257: 40.0 microM).
"
06/01/1990 - "
The effects of two specific 5-lipoxygenase inhibitors AA-863 and U-60,257 (piriprost) on the growth of two human glioma cell lines, U-343 MGa and U-251 MG were investigated.
"
06/01/1990 - "
Effects of the 5-lipoxygenase inhibitors AA-863 and U-60,257 on human glioma cell lines.
"
2.
Neoplasms (Cancer)
06/01/1990 - "
The experiments made on the tumor spheroids suggested an inhibitory effect on proliferation and volume growth already at lower doses (AA-863: 0.4-2.0 microM, U-60,257: 1.0-5.0 microM), a dose range where effects were not found in monolayers.
"
3.
Necrosis
06/01/1990 - "
At higher doses (AA-863: 10.0-30.0 microM, U-60,257: 30.0-90.0 microM) the experiments with spheroids failed to demonstrate a further inhibitory effect on spheroid volume, probably attributed to phenomena such as swelling of cells, dissociation of spheroid structure and development of necrosis.
"
Related Drugs and Biologics
1.
piriprost
2.
Lipoxygenase Inhibitors