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ZK 95962
inhibits photosensitive seizures in man; a selective benzodiazepine receptor agonist; structure given in first source
Also Known As:
ZK-95962
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Carbolines: 283
ZK 95962: 2
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Carbolines: 283
ZK 95962: 2
3-Ring Heterocyclic Compounds
Carbolines: 283
ZK 95962: 2
Related Diseases
1.
Generalized Epilepsy
03/01/1990 - "
A single-dose study of the beta-carboline, ZK 95962, on photosensitive generalized paroxysmal activity in the EEG was conducted in 6 patients with primary generalized epilepsy.
"
2.
Seizures (Absence Seizure)
03/01/1990 - "
Inhibition of photosensitive seizures in man by the beta-carboline, ZK 95962, a selective benzodiazepine receptor agonist.
"
09/01/1987 - "
Derivatives of ethyl-beta-carboline-3-carboxylate, ZK 91296, ZK 93423 and ZK 95962 have potent anticonvulsant activity against sound-induced seizures in audiogenic DBA/2 mice and against photically-induced seizures in the baboon, Papio papio.
"
3.
Myoclonus (Nocturnal Myoclonus)
03/01/1990 - "
The feelings of uneasiness and myoclonic jerks, provoked by photostimulation, were also abolished by ZK 95962, but not by placebo injections.
"
4.
Body Weight (Weight, Body)
03/01/1990 - "
A double-blind cross-over study with 2 injections of ZK 95962 (20 micrograms/kg body weight repeated 10 min after 1st injection) and 2 placebo injections were carried out in a randomized order, with 4 h intervals between the injections with active drug and placebo.
"
Related Drugs and Biologics
1.
norharman
2.
GABA-A Receptors (GABA(A) Receptor)
3.
Anticonvulsants (Antiepileptic Drugs)
4.
ZK 93423
5.
ZK 91296
6.
beta-carboline-3-carboxylic acid ethyl ester
Related Therapies and Procedures
1.
Injections