WL 19

structure given in first source; angiotensin II type 2 receptor antagoinst

Also Known As:

1-(3-methyl-4-methoxyphenyl)-methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)pyridine-6-carboxylic acid; EMA300; PD 121981; PD-121981; WL-19

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - WL 19: 3
  - Pyridines: 88
    - WL 19: 3

Experts

1.	Smith, Maree T: 3 articles (01/2017 - 05/2013)
2.	Muralidharan, Arjun: 2 articles (01/2017 - 10/2013)
3.	Wyse, Bruce D: 2 articles (10/2013 - 05/2013)
4.	Khan, Nemat: 1 article (01/2017)
5.	Walther, Thomas: 1 article (10/2013)
6.	Woodruff, Trent M: 1 article (10/2013)
7.	Edwards, Stephen R: 1 article (05/2013)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 10/01/2013 - "Lumbar dorsal root ganglia (DRGs) were removed for investigation of the mechanism through which EMA300 alleviates neuropathic pain. " 10/01/2013 - "This study was designed to elucidate the mechanism through which EMA300, a small molecule antagonist of the angiotensin II type 2 receptor (AT₂R) with >1,000-fold selectivity over the angiotensin II type 1 receptor, produces analgesia in a rodent model of neuropathic pain. " 10/01/2013 - "Augmented angiotensin II/AT₂R signaling in the DRGs of CCI rats is attenuated by EMA300 to block p38 MAPK and p44/p42 MAPK activation, a mechanism with clinical validity for alleviating neuropathic pain."
2.	Pain (Aches) 05/01/2013 - "In CCI rats, single intraperitoneal bolus doses of EMA200, EMA300, and EMA400 evoked dose-dependent pain relief. "
3.	Hypersensitivity (Allergy) 01/01/2017 - "To address this issue, groups of adult male Sprague-Dawley rats with fully developed unilateral hindpaw hypersensitivity, following chronic constriction injury (CCI) of the sciatic nerve, received a single intraperitoneal bolus dose of the small molecule AT2 receptor antagonist, EMA300 (10 mg kg-1), or vehicle. "

Related Drugs and Biologics

1.	Type 1 Angiotensin Receptor
2.	Type 2 Angiotensin Receptor
3.	p38 Mitogen-Activated Protein Kinases
4.	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)
5.	Angiotensin II
6.	PD 123319
7.	EMA400

Related Therapies and Procedures

1.	Analgesia