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3'- O- benzyl- 2'- deoxy- 5- trifluoromethyluridine
structure given in first source
Also Known As:
3'-O-benzyl-alpha, alpha, alpha-trifluorothymidine; 3-BDTFU; FTC-092
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleosides: 50
Thymidine: 4460
Trifluridine: 262
3'-O-benzyl-2'-deoxy-5-trifluoromethyluridine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
Thymidine: 4460
Trifluridine: 262
3'-O-benzyl-2'-deoxy-5-trifluoromethyluridine: 1
Deoxyribonucleosides: 34
Thymidine: 4460
Trifluridine: 262
3'-O-benzyl-2'-deoxy-5-trifluoromethyluridine: 1
Related Diseases
1.
Sarcoma 180
01/01/1991 - "
The ED50 value for FTC-092 the dose effective in achieving 50% inhibition of tumor growth against the solid form of sarcoma 180 was 13.3 mg/kg daily, whereas those for 5-trifluoromethyl-2'-deoxyuridine (CF3dUrd), the parent compound of FTC-092, for 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, FT), the prodrug of 5-fluorouracil (FUra), and for FUra were 64.1, 122, and 28 mg/kg daily, respectively.
"
2.
Neoplasms (Cancer)
01/01/1991 - "
The ED50 value for FTC-092 the dose effective in achieving 50% inhibition of tumor growth against the solid form of sarcoma 180 was 13.3 mg/kg daily, whereas those for 5-trifluoromethyl-2'-deoxyuridine (CF3dUrd), the parent compound of FTC-092, for 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, FT), the prodrug of 5-fluorouracil (FUra), and for FUra were 64.1, 122, and 28 mg/kg daily, respectively.
"
Related Drugs and Biologics
1.
Trifluridine (Viroptic)
2.
Prodrugs
3.
Tegafur
4.
Fluorouracil (Carac)