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nanterinone
structure given in first source
Also Known As:
6-(2,4-dimethyl-1H-imidazol-1-yl)-8-methyl-2(1H)-quinolinone; UK 61260; UK-61,260
Networked:
3
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
nanterinone: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Quinolones: 2938
nanterinone: 3
Related Diseases
1.
Heart Failure
06/01/1992 - "
The phosphodiesterase inhibitor UK 61260 exhibits positive inotropic activity in animal studies and is under clinical investigation for treatment of congestive heart failure (CHF).
"
05/01/1996 - "
Acute hemodynamic effects and preload-dependent cardiovascular profile of the partial phosphodiesterase inhibitor nanterinone in patients with mild to moderate heart failure.
"
05/01/1996 - "
As its acute hemodynamic effects in humans are unknown, an oral dose of 2 mg nanterinone was studied in 14 patients with heart failure (NYHA class II-III) on chronic diuretic and angiotensin-converting enzyme (ACE) inhibitor treatment.
"
2.
Arteritis
01/01/1995 - "
Infusion of rats with 72 or 144 mg/kg FM produced arteritis over a wider range of tissues than did UK-61,260.
"
01/01/1995 - "
Infusion of UK-61,260 at doses of 100, 300 or 400 mg/kg produced arteritis mainly in the mesenteric arteries and occasionally in the renal, pancreatic, gastric and coronary arteries.
"
01/01/1995 - "
Characterization of the arteritis induced by infusion of rats with UK-61,260, an inodilator, for 24 h.
"
01/01/1995 - "
The similarity between arteritis induced in rats by fenoldopam or by UK-61,260, at doses inducing PDE III inhibition, is consistent with the view that they have a similar pathogenesis.
"
01/01/1995 - "
In this study we characterized the arteritis induced by UK-61,260, an investigational inotropic agent with vasodilatory properties which displays an inhibitory action on cyclic AMP phosphodiesterase, in comparison with lesions induced by FM.
"
Related Drugs and Biologics
1.
Phosphodiesterase Inhibitors
2.
Phosphoric Diester Hydrolases (Phosphodiesterases)
3.
Cyclic AMP (AMP, Cyclic)
4.
Fenoldopam (Corlopam)
5.
Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
6.
Diuretics
7.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)