preprocathepsin B

precursor of EC 3.4.22.1

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 02/25/1994 - "Four full-length cDNA clones coding for preprocathepsin B were isolated from a human gastric adenocarcinoma cDNA library (AGS 1-6-30-1) and analyzed for possible sequence modifications that might be linked to altered intracellular trafficking and secretion of cathepsin B (CTSB) in malignant tumors. "
2.	Melanoma (Melanoma, Malignant) 01/01/1991 - "As all three messages encoded normal preprocathepsin B, cathepsin B secretion by melanoma cells is probably due to posttranslational mechanisms and not to alternative splicing or gene mutation."
3.	Hepatocellular Carcinoma (Hepatoma) 10/01/1986 - "To further our investigations on the structure, mode of biosynthesis, and intracellular sorting of this enzyme, we have determined the complete coding sequences for human and mouse preprocathepsin B by using cDNA clones isolated from human hepatoma and kidney phage libraries. "
4.	Adenocarcinoma 02/25/1994 - "Four full-length cDNA clones coding for preprocathepsin B were isolated from a human gastric adenocarcinoma cDNA library (AGS 1-6-30-1) and analyzed for possible sequence modifications that might be linked to altered intracellular trafficking and secretion of cathepsin B (CTSB) in malignant tumors. "