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ADN 138
structure given in first source
Also Known As:
8'-chloro-2',3'-dihydrospiro(pyrrolidine-3,6'(5'H)-pyrrolo(1,2,3-de)(1,4)benzoxazine)-2,5,5'-trione; ADN-138; Spiro(pyrrolidine-3,6'(5'H)-pyrrolo(1,2,3-de)(1,4)benzoxazine)-2,5,5'-trione, 8'-chloro-2',3'-dihydro-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Pyrroles: 369
ADN 138: 1
Oxazines: 9
ADN 138: 1
Related Diseases
1.
Hyperglycemia
05/01/1988 - "
These results suggest that the increased polyol pathway activity in the hyperglycemia may be involved in the development of electroretinogram abnormalities similar to those in human diabetes; therefore, ADN-138 could be a useful drug for therapy of retinopathy in the early diabetic stage.
"
05/01/1988 - "
Diabetic hyperglycemia-associated abnormalities were prevented and normalized by insulin or ADN-138, an aldose reductase inhibitor.
"
05/01/1988 - "
Polyol accumulation was prevented by insulin or ADN-138, and the elevated polyol level was reversed by insulin, ADN-138, or withdrawal of galactose in diabetic hyperglycemia and/or galactosemia.
"
2.
Galactosemias (Galactosemia)
05/01/1988 - "
Galactosemia-induced abnormalities were inhibited by ADN-138, and were reversed either by ADN-138 treatment or by withdrawal of galactose from the diet.
"
05/01/1988 - "
Polyol accumulation was prevented by insulin or ADN-138, and the elevated polyol level was reversed by insulin, ADN-138, or withdrawal of galactose in diabetic hyperglycemia and/or galactosemia.
"
Related Drugs and Biologics
1.
Insulin (Novolin)
2.
Galactose (Galactopyranose)
3.
Aldehyde Reductase (Aldose Reductase)
4.
polyol
Related Therapies and Procedures
1.
Therapeutics