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leucine thiorphan
enkephalinase inhibitor
Also Known As:
Leu-thiorphan
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Sulfur Amino Acids: 221
Thiorphan: 64
leucine thiorphan: 2
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Glycine: 5151
N-substituted Glycines
Thiorphan: 64
leucine thiorphan: 2
Sulfur Amino Acids: 221
Thiorphan: 64
leucine thiorphan: 2
Related Diseases
1.
Cough
09/01/1989 - "
Enkephalinase (120 micrograms) inhibited cough induced by subsequent exposure to substance P compared with the response to substance P alone, but after further exposure to the enkephalinase inhibitor leucine-thiorphan (10(-5) M), substance P increased cough significantly.
"
12/01/1988 - "
Leucine-thiorphan (10(-5) M) and phosphoramidon (10(-5) M) potentiated substance P-induced cough; NEP inhibitors also potentiated capsaicin-induced cough significantly.
"
12/01/1988 - "
To study the roles of substance P and endogenous neutral endopeptidase in mediating cough, we measured cough responses in awake guinea pigs in response to exogenous substance P and capsaicin aerosols in the presence and absence of the neutral endopeptidase inhibitors leucine-thiorphan and phosphoramidon.
"
Related Drugs and Biologics
1.
Neprilysin (Neutral Endopeptidase)
2.
Substance P
3.
Capsaicin (Zostrix)
4.
Aerosols
5.
phosphoramidon