HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
ICI 164384
structure given in first source
Also Known As:
ICI 164 384; ICI-164384; N-n-butyl-N-methyl-11-(3,17beta-dihydroxyestra-1,3,5(10)-trien-7alpha-yl)undecanamide; Estra-1,3,5(10)-triene-7-undecanamide, N-butyl-3,17-dihydroxy-N-methyl-, (7alpha,17beta)-
Networked:
18
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Estranes
Estrenes
Estradiol: 14115
ICI 164384: 18
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Gonadal Hormones: 716
Gonadal Steroid Hormones: 7657
Estradiol Congeners: 358
Estradiol: 14115
ICI 164384: 18
Organic Chemicals: 133
Amides: 2428
Polyunsaturated Alkamides
ICI 164384: 18
Hydrocarbons: 1713
Acyclic Hydrocarbons
Alkenes: 265
Polyunsaturated Alkamides
ICI 164384: 18
Alkynes: 217
Polyunsaturated Alkamides
ICI 164384: 18
Related Diseases
1.
Premature Obstetric Labor (Premature Labor)
10/01/1998 - "
Results showed the following: 1) NOS II mRNA expression in the rat uterus was substantially increased during pregnancy and decreased during labor at term; 2) RU-486 (an antagonist of progesterone) induced preterm labor and was associated with a marked decrease in NOS II mRNA expression to 60.9%, 20.3%, and 2.9% at, respectively, 6, 12, and 24 h after treatment compared with the control value (100%); 3) progesterone administration in pregnant rats significantly increased uterine NOS II gene expression (374.1% vs. 100%); 4) NOS II mRNA in the uterus was significantly reduced by prostaglandin F2alpha (PGF2alpha; 11.6% vs. 100% in control); 5) treatment with progesterone prevented PGF2alpha-induced inhibition in NOS II mRNA expression; 6) ICI 164384, an antiestrogen, significantly increased serum progesterone concentration and stimulated NOS II expression by the uterus in a time-dependent manner; 7) as shown by immunofluorescent studies, cells stained by NOS II antibodies were apparent in the decidual compartment as well as in areas between myometrial cell bundles in the pregnant rat uterus.
"
2.
Breast Neoplasms (Breast Cancer)
03/25/1999 - "
The ability of the antiestrogen ICI 164 384 to suppress the proliferation of ER-negative breast cancer cells that reexpress ER might be useful ultimately as an endocrine gene therapy approach for controlling the growth of ER-negative breast cancer cells.
"
05/01/1989 - "
Initial experiments investigated the effects of ICI 164384, a pure estrogen antagonist, on proliferation kinetics in asynchronous cultures of MCF-7 human breast cancer cells.
"
08/01/1996 - "
Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.
"
01/01/1996 - "
Using T-47D human breast cancer cells, we compared the effects of retinoic acid (RA) and the antiestrogen ICI 164384 on cell cycle phase distribution and the expression of genes with known functions in cell cycle control.
"
11/01/1995 - "
The effect of ICI 164384 and beta-interferon on the growth and steroid receptor profile of breast cancer cell lines.
"
3.
Neoplasms (Cancer)
05/01/1994 - "
Interestingly, ICI 164384 exerted an antiproliferative action also an estrogen receptor-negative cell lines, probably through an alternative mechanism non estrogen receptor-mediated, supporting the hypothesis that it could be effective on estrogen receptor-positive as well as estrogen receptor-negative tumors.
"
01/01/1994 - "
It was, therefore, our interest to determine whether the combination of the antiprogestin, onapristone (ON), and the pure antiestrogen, ICI 164384 (ICI) might provide a more effective therapy than either monotherapy in experimental mammary tumors containing both estrogen and progesterone receptors.
"
4.
Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/01/1991 - "
At non-cytotoxic concentrations, ICI 164384 potentiated the cytotoxicity of doxorubicin in a dose-dependent manner in both the classical multi-drug resistant (MDR) human leukaemia cell lines CEM/VLB 100 and CEM/VLB 1000 and the human small cell lung cancer cell line H69 LX4.
"
5.
Necrosis
08/01/1996 - "
(ii) TAM and OH-TAM at 10(-5) M, but not ICI 164 384, caused lytic cell death (necrosis) within 24 h, which was not inhibited by estradiol (10(-9)-10(-6)M).
"
Related Drugs and Biologics
1.
Estrogen Receptor Modulators (Antiestrogen)
2.
Messenger RNA (mRNA)
3.
Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
4.
Mifepristone (RU 486)
5.
Dinoprost
6.
Progesterone
7.
Antibodies
8.
Estrogens (Estrogen)
9.
afimoxifene (hydroxytamoxifen)
10.
Tamoxifen
Related Therapies and Procedures
1.
Aftercare (After-Treatment)
2.
Therapeutics