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vadocaine
RN given refers to parent cpd
Also Known As:
2',4'-dimethyl-6'-methoxy-3-(2-methylpiperidyl)propionanilide; OR-K-242; vadocaine hydrochloride
Networked:
6
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperidines: 17
vadocaine: 6
Related Diseases
1.
Cough
04/01/1988 - "
Vadocaine is sufficiently safe for future clinical trials in patients with cough.
"
04/01/1988 - "
However, statistically significant rises from the pre-dose value in the cough threshold stimulus level were observed following 10 and 30 mg doses of vadocaine.
"
04/01/1988 - "
In cats, vadocaine (3 mg/kg i.v.) inhibited by about 80% for 10 min the cough reflex initiated by mechanical irritation of the trachea.
"
04/01/1988 - "
In dogs, both oral and intravenous doses of 6 mg/kg of vadocaine and 2 mg/kg of codeine were approximately equiactive, inhibiting by 60-80% the cough induced by electrical stimulation of the trachea.
"
04/01/1988 - "
In another cat model, 5 mg/kg of vadocaine was somewhat weaker than 1 mg/kg of codeine in inhibiting the cough caused by electrical stimulation of the laryngeal nerve (Domenjoz' method).
"
2.
Atrioventricular Block
04/01/1988 - "
The acute toxic dose of vadocaine in rats ranged from 64 to 100 mumol/kg i.v.; lidocaine and codeine caused no lethalities in rats at the dose range 1-64 mumol/kg i.v. In guinea-pigs, the lethal dose of 64 mumol/kg i.v. produced AV blocks followed by asystole or ventricular fibrillation.
"
3.
Weight Loss (Weight Reduction)
04/01/1988 - "
Spontaneous or precipitated withdrawal from repeated vadocaine or OR K-269-HCl administration caused neither hypothermia, weight loss nor behavioural changes.
"
04/01/1988 - "
Moreover, spontaneous and precipitated withdrawal-induced hypothermia, weight loss and behavioural changes from repeated codeine, vadocaine and OR K-269-HCl administrations were studied.
"
04/01/1988 - "
The effects of two novel antitussive compounds, vadocaine hydrochloride (2',4'-dimethyl-6'-methoxy-3-(2-methylpiperidyl)propionanilide+ ++ hydrochloride, OR K-242-HCl; INN: vadocaine) and N-(2,4-dimethyl-6-methoxyphenyl)-4-(diethylamine)butanamide hydrochloride (OR K-269-HCl) on the suppression of withdrawal signs (hypothermia and weight loss) induced by repeated morphine administration were compared to those of acute morphine and codeine administrations.
"
4.
Ventricular Fibrillation
04/01/1988 - "
The acute toxic dose of vadocaine in rats ranged from 64 to 100 mumol/kg i.v.; lidocaine and codeine caused no lethalities in rats at the dose range 1-64 mumol/kg i.v. In guinea-pigs, the lethal dose of 64 mumol/kg i.v. produced AV blocks followed by asystole or ventricular fibrillation.
"
5.
Hypothermia
04/01/1988 - "
Spontaneous or precipitated withdrawal from repeated vadocaine or OR K-269-HCl administration caused neither hypothermia, weight loss nor behavioural changes.
"
04/01/1988 - "
The effects of two novel antitussive compounds, vadocaine hydrochloride (2',4'-dimethyl-6'-methoxy-3-(2-methylpiperidyl)propionanilide+ ++ hydrochloride, OR K-242-HCl; INN: vadocaine) and N-(2,4-dimethyl-6-methoxyphenyl)-4-(diethylamine)butanamide hydrochloride (OR K-269-HCl) on the suppression of withdrawal signs (hypothermia and weight loss) induced by repeated morphine administration were compared to those of acute morphine and codeine administrations.
"
Related Drugs and Biologics
1.
Codeine (Codeine Phosphate)
2.
vadocaine
3.
Antitussive Agents (Antitussives)
4.
Lidocaine (Xylocaine)
5.
Citric Acid (Citrate)
6.
Methacholine Chloride (Methacholine)
7.
Morphine (MS Contin)
8.
Dextromethorphan (Racemethorphan)
9.
Opioid Analgesics (Opioids)
10.
Ammonia
Related Therapies and Procedures
1.
Induced Hypothermia