N,N-dimethyl-4-anisidine (DMPA)

08/01/1996 - " Only pain at menstruation was significantly greater in women in the OC group (because of the absence of regular flow in subjects in the DMPA group). "
08/01/2004 - "This study was done to see if pinching the skin, prior to injection of DMPA, would reduce the pain of the injection, as suggested by the gate theory. "
09/01/2013 - "This is a planned secondary analysis of a randomized controlled trial comparing pain between DMPA-IM and DMPA-SC. "
02/01/2013 - "Half of the patients had recurrent pain five years after DMPA treatment ended."
02/01/2013 - "The cumulative recurrence rates of pain after DMPA treatment were 18%, 28%, 41%, 46%, and 50% at months 12, 24, 36, 48, and 60, respectively. "

09/01/2012 - "The current study examined the effect of DOX compared to placebo in treating a current bleeding episode during DMPA use. "
04/01/1999 - "In contrast with previous suggestions, in this study, irregular bleeding was not an important medical reason for discontinuation of DMPA use. "
09/29/2021 - "DMPA-IM often causes no or scanty menstruation; we hypothesized that this may have a protective effect on getting HIV, by reducing exposure to HIV during menstrual bleeding.This"
11/01/2018 - "Logistic regressions indicated that higher quality during the initial counseling session is related to the likelihood of getting another dose of DMPA-SC (OR=2.04; 95% CI: 1.12-3.47) whereas experiencing more bleeding reduced the likelihood of continuation after 3 months (OR=0.15; 95% CI: 0.07-0.34). "
01/01/2013 - " NET-EN plus E (2) V group also had more regular bleeding and fewer prolonged bleeding reference periods than the DMPA plus E(2)C group. "

07/01/2016 - "DMPA Suppresses Cell Proliferation and Enhances Cell Apoptosis of Eutopic Endometrium in Women with Endometriosis: A Randomized Controlled Study."
02/01/2013 - "Sixty-one patients with symptomatic endometriosis, who had been treated with DMPA for 15 months and were satisfied with the treatment, were included in the present study. "
07/01/2016 - "Three months of 150 mg DMPA treatment could suppress cell proliferation and enhance cell apoptosis of the eutopic endometrium of women with endometriosis."
07/01/2016 - "To investigate the effects of DMPA on cell proliferation and apoptosis in the eutopic endometrium of women with endometriosis. "
01/01/2016 - "Similarly, the presence of the 2 highly correlated variables endometriosis and DMPA treatment statistically but not clinically significantly increased the risk of incident DM. "

05/01/1996 - " A WHO hospital-based study of the relationship between endometrial cancer and DMPA use found a protective effect of DMPA which appeared to be longterm and as great as that associated with OCs. "
01/01/1995 - " Its hematological parameters are good and some studies showed that DMPA does not increase the risk of development of cancer of the endometrium, ovaries, and cervix. "
10/01/2023 - "Endometrial cancer risk declined by 3% (aOR, 0.97 [95% CI, 0.96-0.98]) for every 3 months of DMPA use. "
10/01/2023 - "Ever use of DMPA was associated with a 70% decreased overall risk of endometrial cancer (aOR, 0.30 [95% CI, 0.21-0.42]). "
12/01/2001 - "Data on DMPA have shown a number of noncontraceptive and therapeutic benefits, the most prominent of which is an 80% reduction in the risk of endometrial cancer. "

03/19/2006 - "Our findings indicate that vaginal bleeding due to DMPA can be successfully treated, leading to improvement in continuation rates."
03/19/2006 - "A total of 131 patients who reported vaginal bleeding while on DMPA were included in this study and 83 were treated with monophasic OCP. "
06/01/2011 - "Irregular uterine bleeding with DMPA associated with increased perfusion of uterine and subendometrial blood vessels."
06/01/2011 - "Forty users of DMPA were divided into two groups: one group included 20 users with irregular uterine bleeding and the second group included 20 amenorrheic users. "
06/01/2011 - "Transvaginal Doppler sonography for evaluation of irregular uterine bleeding with DMPA."