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MDL 72567
structure given in first source
Also Known As:
3-(2-furoyl)-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine; MDL-72567; 3-Pyridinecarboxylic acid, 5-(2-furanylcarbonyl)-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl ester
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Dihydropyridines: 214
MDL 72567: 2
Related Diseases
1.
Tachycardia (Tachyarrhythmias)
10/01/1987 - "
Thus, in these experiments, MDL 72567 caused less reflex tachycardia for a given fall in blood pressure than nifedipine and was less likely to cause myocardial depression.
"
07/01/1987 - "
When compared with nifedipine, MDL 72567 caused less reflex tachycardia for a given fall in blood pressure, in anesthetized beagles and in conscious renal hypertensive dogs.
"
07/01/1987 - "
Thus, although MDL 72567 appears to cause a direct myocardial slowing that can partially offset reflex tachycardia, the compound has negligible negative inotropic effects and may therefore be useful in angina pectoris or even in congestive heart failure.
"
2.
Bradycardia
10/01/1987 - "
Nifedipine did not change heart rate in SA-denervated rats, whereas MDL 72567 caused bradycardia.
"
07/01/1987 - "
MDL 72567, a dihydropyridine calcium-antagonist, that causes vasodilation and direct sinus bradycardia.
"
07/01/1987 - "
Furthermore, in pithed rat preparations infused with angiotensin II to elevate blood pressure, the hypotensive effects of MDL 72567 (3 nmol/kg-3 mumol/kg, intravenously, i.v.) were accompanied by bradycardia, whereas nifedipine, PY 108-068, and nicardipine lowered blood pressure without affecting heart rate.
"
3.
Heart Failure
07/01/1987 - "
Thus, although MDL 72567 appears to cause a direct myocardial slowing that can partially offset reflex tachycardia, the compound has negligible negative inotropic effects and may therefore be useful in angina pectoris or even in congestive heart failure.
"
4.
Angina Pectoris
07/01/1987 - "
Thus, although MDL 72567 appears to cause a direct myocardial slowing that can partially offset reflex tachycardia, the compound has negligible negative inotropic effects and may therefore be useful in angina pectoris or even in congestive heart failure.
"
Related Drugs and Biologics
1.
Nifedipine (Adalat)
2.
Nicardipine (Dagan)
3.
Calcium
4.
Angiotensin II
5.
1,4-dihydropyridine (dihydropyridine)
6.
darodipine