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hemopexin receptor
Also Known As:
haemopexin receptors; receptor, hemopexin
Networked:
5
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Membrane Proteins: 10078
Cell Surface Receptors: 2125
Peptide Receptors: 1159
hemopexin receptor: 5
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
06/15/1988 - "
Results of binding studies using mouse hepatoma cells and isolated domains indicate that domain I not only binds heme but also plays a vital part in the hemopexin-receptor interaction.
"
04/15/1988 - "
Competitive inhibition and saturation studies demonstrate that FeTPPS-hemopexin binds to the hemopexin receptor on mouse hepatoma cells but with a lower affinity (Kd 125 nM) more characteristic of apo-hemopexin than heme-hemopexin (Kd 65 nM).
"
06/01/1991 - "
Haemopexin receptors from mouse hepatoma (Hepa) cells were affinity-labelled by cross-linking to haem-125I-haemopexin complexes using two homo-[disuccinimidyl suberate (DSS) and 3,3'-dithiobis(succinimidyl propionate) (DTSSP)] and one hetero-[sulphosuccinimidyl 4-(p-maleimidophenyl)butyrate (sulpho-SMPB)] bifunctional cross-linking agents.
"
06/15/1988 - "
Importantly, SnPP-hemopexin binds to the hemopexin receptor on mouse hepatoma cells with an affinity comparable to that of heme-hemopexin and treatment of the hepatoma cells with SnPP-hemopexin causes a rapid increase in the steady state level of heme oxygenase messenger RNA.
"
2.
Leukemia
06/25/1987 - "
Immunoinhibition experiments using the antibody against the placental receptor revealed inhibition of binding of 125I-hemopexin to human leukemia K562 and HL 60 cells, thereby strongly supporting that the polypeptide isolated from the human placenta was the hemopexin receptor.
"
Related Drugs and Biologics
1.
Heme (Haem)
2.
Hemopexin
3.
Messenger RNA (mRNA)
4.
Peptides (Polypeptides)
5.
Heme Oxygenase (Decyclizing) (Heme Oxygenase)
6.
succinimidyl 4-(4-maleimidophenyl)butyrate
7.
3,3'-dithiobis(sulfosuccinimidyl propionate)
8.
disuccinimidyl suberate
9.
dithiobis(succinimidylpropionate)