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1'-hydroxy-2',3'-dehydroestragole
synthetic acetylenic analog of estragole; structure given in first source
Also Known As:
OHDHE
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Phenyl Ethers: 8
Anisoles
1'-hydroxy-2',3'-dehydroestragole: 3
Ethers: 242
Methyl Ethers: 19
Anisoles
1'-hydroxy-2',3'-dehydroestragole: 3
Phenyl Ethers: 8
Anisoles
1'-hydroxy-2',3'-dehydroestragole: 3
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
05/01/1987 - "
The acetylenic compounds 1'-hydroxy-2',3'-dehydroestragole and 1'-hydroxy-2',3'-dehydrosafrole were the most potent derivatives studied; they were 5- and 10-fold more potent (based on the average numbers of hepatomas per liver) than the corresponding allylic benzene derivatives.
"
08/01/1986 - "
DNA from each of 25 hepatomas, induced by N-hydroxy-2-acetylaminofluorene, vinyl carbamate, or 1'-hydroxy-2',3'-dehydroestragole, containing transforming activity in the NIH 3T3 transfection assay.
"
11/01/1985 - "
The administration of pentachlorophenol (0.04 mumol/g body weight) 45 min prior to a single dose of 1'-hydroxy-2',3'-dehydroestragole (0.04 mumol/g body weight) in 12-day-old male B6C3F1 mice greatly inhibited (87-97%) the covalent binding of 1'-hydroxy-2',3'-dehydroestragole to hepatic macromolecules and the formation of hepatomas at 10 months.(ABSTRACT TRUNCATED AT 400 WORDS)
"
2.
Body Weight (Weight, Body)
11/01/1985 - "
The administration of pentachlorophenol (0.04 mumol/g body weight) 45 min prior to a single dose of 1'-hydroxy-2',3'-dehydroestragole (0.04 mumol/g body weight) in 12-day-old male B6C3F1 mice greatly inhibited (87-97%) the covalent binding of 1'-hydroxy-2',3'-dehydroestragole to hepatic macromolecules and the formation of hepatomas at 10 months.(ABSTRACT TRUNCATED AT 400 WORDS)
"
Related Drugs and Biologics
1.
Pentachlorophenol (Sodium Pentachlorophenate)
2.
DNA (Deoxyribonucleic Acid)
3.
Dihydrotachysterol (AT 10)
4.
Benzene Derivatives
5.
Alkynes (Acetylenes)
6.
vinyl carbamate