trienomycin A

isolated from Streptomyces sp. No. 83-16; related to ansamycin antibiotics; active against hepatoma cells in vitro; MW 622; MF C36-H50-N2-O7

Also Known As:

19-deoxymycotrienin II; D-Alanine, N-(cyclohexylcarbonyl)-, 11-ester with 20,23-didehydro-20,23-dideoxo-20-hydroxyansatrienol A

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2021 - "The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer." 01/01/2021 - "Trienomycin A exerted anti-neoplastic activity by suppressing STAT3 activation in pancreatic cancer. " 01/01/2021 - "Trienomycin A also inhibited colony formation, proliferation, migration and invasion of pancreatic cancer cell lines. " 01/01/2021 - "Here, we identified the natural product trienomycin A (TA), an ansamycin antibiotic, as a potential inhibitor of the STAT3 pathway with potent activity against pancreatic cancer. "
2.	Neoplasms (Cancer) 12/01/1987 - "Antitumor activity of trienomycin A on murine tumors." 12/01/1987 - "The antitumor activity of a novel ansamycin antibiotic, trienomycin A, against various murine tumors was studied with two treatment schedules. "

1.	Rifabutin (Ansamycin)
2.	Anti-Bacterial Agents (Antibiotics)