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ascaridole

monoterpene endoperoxide with anthelmintic properties; structure given in first source

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Gille, Lars: 2 articles (08/2022 - 01/2017)
2.	Blömeke, Brunhilde: 2 articles (10/2015 - 09/2014)
3.	Chatterjee, Mitali: 1 article (08/2022)
4.	De Sarkar, Sritama: 1 article (08/2022)
5.	Sarkar, Deblina: 1 article (08/2022)
6.	Bacher, Markus: 1 article (01/2017)
7.	Geroldinger, Gerald: 1 article (01/2017)
8.	Hettegger, Hubert: 1 article (01/2017)
9.	Monzote, Lianet: 1 article (01/2017)
10.	Rosenau, Thomas: 1 article (01/2017)

Related Diseases

1.	Cutaneous Leishmaniasis 01/01/2017 - "We have shown in the past that the EP ascaridole (Asc) is useful for the treatment of cutaneous leishmaniasis in a mouse model. " 08/01/2022 - "Endoperoxides like ascaridole have emerged as promising anti-parasitic candidates, and its effectiveness was established in an animal model of cutaneous leishmaniasis (CL). "
2.	Sarcoma 180 08/01/2009 - "In conclusion, ascaridole has an interesting antitumor activity in sarcoma 180 murine model, probably related to the described cytotoxic activity, and, moreover, its presence in the essential oil from the leaves of C. " 08/01/2009 - "The in vivo study, using sarcoma 180 as a tumor model, demonstrated inhibition rates of 28.1 and 31.8% for essential oil, at the 50 and 100 mg/kg, while ascaridole inhibition rates were 33.9% at 10 mg/kg and 33.3% at 20-mg/kg doses. "
3.	Neoplasms (Cancer) 08/01/2009 - "The in vivo study, using sarcoma 180 as a tumor model, demonstrated inhibition rates of 28.1 and 31.8% for essential oil, at the 50 and 100 mg/kg, while ascaridole inhibition rates were 33.9% at 10 mg/kg and 33.3% at 20-mg/kg doses. "
4.	Allergic Contact Dermatitis 09/01/2014 - "Oxidation of tea tree oil results in degradation products, such as ascaridole, which may cause allergic contact dermatitis. " 10/01/2015 - "The monoterpene ascaridole, a fairly stable endoperoxide found in essential oils such as tea tree oil can provoke allergic contact dermatitis which has been evidenced under patch test conditions. "
5.	Hypersensitivity (Allergy) 01/01/2016 - "Ascaridole, the oxidative metabolite of α-terpinene, is considered to be one of the components responsible for the contact allergy associated with essential oils derived from Chenopodium and Melaleuca species. "

Related Drugs and Biologics

1.	Volatile Oils (Essential Oils)
2.	Dihydrotachysterol (AT 10)
3.	Tea Tree Oil
4.	Monoterpenes (Monoterpenoids)