polyethylene glycol(B1)- insulin

Also Known As:

insulin, polyethylene glycol(B1)-; B1-polyethylene-glycol-insulin; PEG insulin; PEGylated insulin; insulin, PEG-

Networked: 8 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Insulins: 644
        Proinsulin: 1195
        Insulin: 113363
        polyethylene glycol(B1)- insulin: 8
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptide Hormones: 1347
    - Pancreatic Hormones: 113
      - Insulins: 644
        Proinsulin: 1195
        Insulin: 113363
        polyethylene glycol(B1)- insulin: 8
Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Ethylene Glycols: 8
      - Polyethylene Glycols: 3865
        polyethylene glycol(B1)- insulin: 8
Macromolecular Substances: 97
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - polyethylene glycol(B1)- insulin: 8
Biomedical and Dental Materials
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - polyethylene glycol(B1)- insulin: 8
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyethylene Glycols: 3865
        polyethylene glycol(B1)- insulin: 8

Experts

1.	Metzger, Friedrich: 3 articles (01/2017 - 04/2012)
2.	Tong, Fei: 2 articles (01/2018 - 01/2016)
3.	Saenger, Stefanie: 2 articles (01/2017 - 09/2012)
4.	Hoeflich, Andreas: 2 articles (09/2012 - 04/2012)
5.	Li, Xuejun: 1 article (01/2018)
6.	Liu, Suhuan: 1 article (01/2018)
7.	Ruan, Shiwei: 1 article (01/2018)
8.	Yan, Bing: 1 article (01/2018)
9.	Yang, Shuyu: 1 article (01/2018)
10.	Berretta, Antonio: 1 article (01/2017)

Related Diseases

1.	Ischemia 01/01/2017 - "PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia." 01/01/2016 - "Sprague Dawley rats were pretreated with 30 U/kg insulin or insulin/PEG-b-(PELG-g-PLL) complex, and then subjected to 45 minutes of ischemia and 24 hours of reperfusion. " 01/01/2016 - "Both insulin and insulin/PEG-b-(PELG-g-PLL) preconditioning improved the recovery of renal function, reduced pulmonary oxidative stress injury, restrained inflammatory damage, and downregulated the expression of HIF-1α and VEGF as compared to ischemia/reperfusion group, while insulin/PEG-b-(PELG-g-PLL) significantly improved this effect. "
2.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 09/01/2012 - "Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity."
3.	Diabetes Mellitus 01/01/2018 - "Endogenous ornithine decarboxylase/polyamine system mediated the antagonist role of insulin/PEG-CMCS preconditioning against heart ischemia/reperfusion injury in diabetes mellitus." 04/01/2014 - "The basal insulin analogue LY2605541, a PEGylated insulin lispro with prolonged duration of action, was previously shown to be associated with modest weight loss in Phase 2, randomized, open-label trials in type 2 (N=288) and type 1 (N=137) diabetes mellitus (T2DM and T1DM), compared with modest weight gain with insulin glargine. "
4.	Weight Loss (Weight Reduction) 04/01/2014 - "The basal insulin analogue LY2605541, a PEGylated insulin lispro with prolonged duration of action, was previously shown to be associated with modest weight loss in Phase 2, randomized, open-label trials in type 2 (N=288) and type 1 (N=137) diabetes mellitus (T2DM and T1DM), compared with modest weight gain with insulin glargine. "
5.	Weight Gain 04/01/2014 - "The basal insulin analogue LY2605541, a PEGylated insulin lispro with prolonged duration of action, was previously shown to be associated with modest weight loss in Phase 2, randomized, open-label trials in type 2 (N=288) and type 1 (N=137) diabetes mellitus (T2DM and T1DM), compared with modest weight gain with insulin glargine. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Insulin Lispro (Humalog)
5.	LY2605541
6.	Insulin Glargine (Lantus)
7.	Polyamines
8.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
9.	ethylglyoxal bis(guanylhydrazone) (EGBG)