bis(helenalinyl)malonate (BHMN)

2 helenalin moieties joined via malonate ester

Also Known As:

BHMN; Propanedioic acid, bis(2,3,3a,4,4a,5,7a,8,9,9a-decahydro-4a,8-dimethyl-3-methylene-2,5-dioxoazuleno(6,5-b)furan-4-yl) ester, (3aR-(3alpha,4alpha(3'aR*,4'S*,4'aR*,7'aR*,8'R*,9'aR*),4abeta,7aalpha,8alpha,9aalpha))-

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - bis(helenalinyl)malonate: 6

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 04/01/2023 - "Setting a needleless patch (NL patch) as the control intervention, this study assessed the efficacy of a biodegradable hyaluronic acid MN patch (BHMN patch) for atopic dermatitis (AD) patients with dry skin. "
2.	Lymphoid Leukemia 03/10/1983 - "The mode of action of helenalin and bis(helenalinyl) malonate as protein synthesis inhibitors of P-388 lymphocytic leukemia cells was investigated. " 02/01/1988 - "Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo." 01/01/1988 - "Helenalin and bis (helenalinyl) malonate, sesquiterpene lactones, were shown to be cytotoxic against the growth of P-388 lymphocytic leukemia cells in culture. " 08/01/1981 - "Bis(helenalinyl), bis(plenolinyl), bis(2,3-dihydrohelenalinyl), and bis(2,3,11,13-tetrahydrohelenalinyl) esters have been synthesized in an effort to elucidate the role of the two enone alkylating centers, beta-unsubstituted cyclopentenone and alpha-methylene gamma-lactone, as well as the significance of the diester linkage with respect to the enhanced in vivo P-388 lymphocytic leukemia antileukemic activity of bis(helenalinyl) malonate (2) against P-388 lymphocytic leukemia in the mouse. " 02/01/1988 - "Although the parent sesquiterpene lactone, helenalin, and its derivative, bis(helenalinyl)malonate, are structurally related chemically, they demonstrate differences in their antineoplastic activity, with bis(helenalinyl)malonate being much more active against P-388 lymphocytic leukemia cell growth (T/C% = 261) compared with helenalin (T/C% = 162). "
3.	Neoplasms (Cancer) 02/01/1988 - "Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo."
4.	Carcinoma (Carcinomatosis) 12/01/1987 - "Helenalin and bis(helenalinyl)malonate were shown to be cytotoxic against the growth of human KB carcinoma cells. " 12/01/1987 - "Effect of helenalin and bis(helenalinyl)malonate on nucleic acid and protein synthesis in human KB carcinoma cells."

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	helenalin
3.	Lactones
4.	Sesquiterpenes
5.	Nucleic Acids
6.	Proteins (Proteins, Gene)
7.	Protein Synthesis Inhibitors
8.	Esters
9.	Antineoplastic Agents (Antineoplastics)
10.	cyclopentenone