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agrimonolide

anticestodal agent from Chinese medicinal plant Agrimonia pilosa Ledeb

Also Known As:

3,4-dihydro-6,8-dihydroxy-3-(2-(4-methoxyphenyl)ethyl)-1H-2-benzopyran-1-one

Networked: 4 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Isocoumarins: 26
        agrimonolide: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Isocoumarins: 26
        agrimonolide: 4

Experts

1.	Ding, Pingping: 1 article (07/2022)
2.	Liu, Xiaobei: 1 article (07/2022)
3.	Liu, Ying: 1 article (07/2022)
4.	Wang, Changlin: 1 article (07/2022)
5.	Wang, Hui: 1 article (07/2022)
6.	Cheng, Guodong: 1 article (01/2022)
7.	Li, Liping: 1 article (01/2022)
8.	Liu, Jianzhu: 1 article (01/2022)
9.	Liu, Mingchao: 1 article (01/2022)
10.	Qi, Changxi: 1 article (01/2022)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2022 - "Agrimonolide may be a novel therapeutic agent for treating ovarian cancer." 07/01/2022 - "Our study is the first to suggest that agrimonolide acts as a novel apoptosis- and ferroptosis-inducing agent in ovarian cancer cells by targeting SCD1. " 07/01/2022 - "Additionally, agrimonolide attenuated the tumour growth of ovarian cancer in the SKOV-3 xenograft model and significantly downregulated SCD1 in tumour tissues. " 07/01/2022 - "Here, we aimed to reveal the function of agrimonolide on ovarian cancer progression. " 07/01/2022 - "Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells."
2.	Hypoxia (Hypoxemia) 01/01/2022 - "Protective effects of agrimonolide on hypoxia-induced H9c2 cell injury by maintaining mitochondrial homeostasis."
3.	Stomach Neoplasms (Stomach Cancer) 11/09/2016 - "Data from the present study showed that agrimonolide exhibited a high anti-proliferation effect against human gastric cancer AGS cells. " 11/09/2016 - "Inhibition of cell proliferation and triggering of apoptosis by agrimonolide through MAP kinase (ERK and p38) pathways in human gastric cancer AGS cells."
4.	Colonic Neoplasms (Colon Cancer) 01/01/2023 - "This study reported the efficacy and underlying mechanism of agrimonolide (AM) in treating colon cancer. " 01/01/2023 - "Elucidating the Mechanism of Agrimonolide in Treating Colon Cancer Based on Network Pharmacology."
5.	B-Cell Lymphoma (Lymphoma, B Cell) 11/09/2016 - "In addition, it was found that agrimonolide-induced cell apoptosis was associated with the increase in the (Bcl-2 Associated X Protein, BAX)/(B-cell lymphoma-2, Bcl-2) ratio and the activation of cleaved caspase-3. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	bcl-2-Associated X Protein (bcl 2 Associated X Protein)
3.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4.	Reactive Oxygen Species (Oxygen Radicals)