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6-methylthioguanine

Also Known As:

S6-methylthioguanine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Thioguanine: 835
        6-methylthioguanine: 2

Related Diseases

1.

Neoplasms (Cancer)

08/23/1996 - "Because the carcinogenicity of N-nitrosamines depends on formation of O6-alkylguanine in DNA, the formation of the analog S6-methylthioguanine during azathioprine treatment may partly explain the high incidence of cancer after transplantation."
04/01/1986 - "Other alkylpurines, such as O6-methylguanosine, S6-methylthioguanine, O6-ethylguanine, and 3-methyladenine, did not have this effect on extracts of human tumor cells, while O6-methylguanosine and O6-methylguanine inactivated purified methyltransferase from Escherichia coli. "

Related Drugs and Biologics

1.	Nitrosamines
2.	Methyltransferases
3.	DNA (Deoxyribonucleic Acid)
4.	Azathioprine (Imuran)
5.	6'-O-methylguanosine
6.	3-methyladenine
7.	O-(6)-methylguanine

Related Therapies and Procedures

1.	Transplantation