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WR 77913
Also Known As:
S-(3-amino-2-hydroxypropyl)phosporothioate; WR-77913
Networked:
9
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Organophosphorus Compounds: 300
Organophosphates: 1942
Organothiophosphates: 1
Amifostine: 951
WR 77913: 9
Organothiophosphorus Compounds
Organothiophosphates: 1
Amifostine: 951
WR 77913: 9
Sulfur Compounds: 278
Organothiophosphorus Compounds
Organothiophosphates: 1
Amifostine: 951
WR 77913: 9
Related Diseases
1.
Cataract (Cataracts)
01/01/1995 - "
Intraperitoneal pretreatment with 815 mg/kg WR-77913 30 min before irradiation delayed the development of cataracts; mature cataracts required 42 weeks for development.
"
06/01/1991 - "
One of the phosphorothioates, WR-77913 (S-[3-amino-2-hydroxylpropyl]phosphorothioate) was found to inhibit cataract formation in rats after radiation exposure.
"
08/01/1986 - "
Although the mechanism of radioprotection observed remains to be elucidated, WR-77913 clearly prevents radiation-induced cataracts in rats.
"
08/01/1986 - "
All non-protected irradiated animals developed dense cataracts throughout the lens between 90-120 days post-irradiation, while WR-77913 protected animals developed minimal lens opacification through 200 days post-irradiation.
"
08/01/1986 - "
Protection by WR-77913 against radiation-induced cataract formation in rats was observed following intraperitoneal (i.p.) administration of drug (1160 mg/kg) 15-30 min before exposure to 15.3 Gy of Cs-137 whole head irradiation.
"
2.
Neoplasms (Cancer)
01/01/1982 - "
Because of its low toxicity, adequate bone marrow and gut protection at doses equivalent to one quarter MTD and limited protection of the EMT6 tumor, WR-77913 deserves further investigation to determine its value in multiple drug dose regimens and its capability to protect other normal tissues.
"
01/01/1982 - "
Preliminary experiments with the EMT6 tumor show limited tumor protection with a dose of WR-77913 equivalent to 70 per cent of the MTD.
"
11/01/1986 - "
On this basis, tumor levels of WR-77913 were 4.5-fold those of WR-2721, and WR-3689 uptake was 2.7-fold greater than uptake of WR-2721.
"
11/01/1986 - "
Three aminoalkyl phosphorothioates, WR-2721, WR-3689, and WR-77913, were compared as radioprotectors of RIF-1 tumors irradiated in vivo and assayed for cell survival in vitro.
"
08/01/1986 - "
The organ level biodistribution and tumor radioprotective properties of three drugs have been compared: WR-2721 (NSC 296961), WR-3689 (NSC 327729), and WR-77913 (NSC 318809).
"
Related Drugs and Biologics
1.
Amifostine (Ethyol)
2.
Galactose (Galactopyranose)
3.
S- 2- (3- methylaminopropylamino)ethylphosphorothioic acid
4.
Selenious Acid (Selenite)
5.
Streptozocin (Streptozotocin)
6.
pantethine
Related Therapies and Procedures
1.
Lenses