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N- (6- aminohexyl)- 1- naphthalenesulfonamide (W-5)
calmodulin antagonist; RN given refers to parent cpd
Also Known As:
W-5
; N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride
Networked:
8
relevant articles (
3
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Sulfonamides: 2809
N-(6-aminohexyl)-1-naphthalenesulfonamide: 8
Sulfur Compounds: 278
Sulfones: 534
Sulfonamides: 2809
N-(6-aminohexyl)-1-naphthalenesulfonamide: 8
Related Diseases
1.
Neoplasms (Cancer)
11/01/1989 - "
In addition, tumor volumes in a group treated with UFT plus W-7 were significantly smaller than not only those in the untreated group but also those in groups treated with UFT alone, FT alone, W-5 alone, or W-7 alone.
"
11/01/1989 - "
One of 10 nude mice treated with a combination of UFT and W-5 and 3 of 10 nude mice treated with UFT and W-7 did not develop tumors during the experimental period.
"
04/01/1988 - "
In addition, tumor volume in a UFT plus W-7 treated group was significantly less than those not only in the untreated group but also in the UFT alone, FT alone, W-5 alone and W-7 alone treated groups, suggesting a synergistic inhibitory effect on tumor growth.
"
04/01/1988 - "
One of 10 nude mice treated with a combination of UFT and W-5 and 3 of 10 nude mice treated with UFT and W-7 did not develop tumors during the experimental period.
"
01/01/1988 - "
Although treatment with cisplatin alone markedly inhibited lytic activity of the spleen cells from tumor bearing nude mice against the tumor cells, the inhibitory effect was eliminated by combination with W-7 or W-5.
"
2.
Hypoxia (Hypoxemia)
05/01/1986 - "
W-5, a chlorine-deficient derivative of W-7, showed no protection against hypoxia-induced AV nodal conduction disturbances.
"
3.
Carcinoma (Carcinomatosis)
11/01/1989 - "
Effects of N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) on antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (ftorafur, FT) and a mixture of FT and uracil (UFT) were determined in nude mice bearing human ovarian carcinoma (KF cells).
"
12/15/1987 - "
The present study was designed to potentiate the antineoplastic effects of cisplatin by combination with calmodulin antagonists [N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5)] in nude mice bearing human ovarian carcinoma.
"
4.
Hepatocellular Carcinoma (Hepatoma)
11/01/1992 - "
ML-9, an inhibitor for myosin light chain kinase, and W-7, a calmodulin inhibitor, suppressed the efflux of vinblastine and increased the intracellular accumulation of vinblastine, but W-5, an inactive compound for calmodulin, did not so in rat ascites hepatoma AH66 cells, which have a multidrug-resistant phenotype.
"
5.
Ascites
11/01/1992 - "
ML-9, an inhibitor for myosin light chain kinase, and W-7, a calmodulin inhibitor, suppressed the efflux of vinblastine and increased the intracellular accumulation of vinblastine, but W-5, an inactive compound for calmodulin, did not so in rat ascites hepatoma AH66 cells, which have a multidrug-resistant phenotype.
"
Related Drugs and Biologics
1.
W 7 (W7)
2.
Cisplatin (Platino)
3.
Chlorine
4.
Calmodulin (Calcium-Dependent Activator Protein)
5.
Antineoplastic Agents (Antineoplastics)
6.
naphthalenesulfonamide
7.
Fluorouracil (Carac)
8.
Vinblastine (Vinblastine Sulfate)
9.
Uracil
10.
Myosin-Light-Chain Kinase