(ortho-nitrophenyl)sulfenyl pentagastrin

possible gastrin receptors antagonist; in anesthetized rat with continuous gastric perfusion, inhibits gastric acid secretion; RN given refers to 1-((2-nitrophenyl)thio)-L-tryptophyl cpd

Also Known As:

(o-nitrophenyl)sulphenyl pentagastrin; PgNpS; L-phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-1-((2-nitrophenyl)thio)-L-tryptophyl-L-methionyl-L-alpha-aspartyl-

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bhattarai, Shanta: 1 article (11/2021)
2.	Krishnan, Sunil: 1 article (11/2021)
3.	Mackeyev, Yuri: 1 article (11/2021)
4.	Singh, Pankaj K: 1 article (11/2021)
5.	Venkatesulu, Bhanu P: 1 article (11/2021)
6.	Man, Libo: 1 article (01/2021)
7.	Xu, Xiao: 1 article (01/2021)
8.	Amjadi, Sajed: 1 article (04/2019)
9.	Ghorbani, Marjan: 1 article (04/2019)
10.	Hamishehkar, Hamed: 1 article (04/2019)

Related Diseases

1.	Neoplasms (Cancer) 11/25/2021 - "In a murine TNBC xenograft model, CXCR4 targeting potently increased tumor regrowth delay following radiation compared to radiation in the presence of pGNPs or vehicle alone. " 01/11/2019 - "PGNPs fabricated under different conditions, including different deposited Au/Ag content ratios and different alloying annealing temperatures, are compared for optimizing the fabrication condition in terms of LSPR wavelength, PS linkage capability, and cancer cell damage efficiency. " 01/01/2021 - "The results clearly showed that F-PGNPs significantly improved the potency of flutamide by delivering it directly into the nucleus of cancer cells through caveolae-dependent endocytosis. " 01/01/2021 - "PGNPs and flutamide worked synergistically against cancer cells. " 04/01/2019 - "Moreover, the synergistic effect of DOX@BET loaded PGNPs decreased the cell viability amount of breast cancer cells (MCF-7) respect to the free form of DOX or BET which indicated that the developed smart nanocarrier will be a hopeful nanocarrier for cancer therapy."
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2021 - "Thus, the greater inhibitory effect of F-PGNPs over the pure drug would be of great advantage during prostate cancer treatment." 01/01/2021 - "The efficacy of F-PGNPs (IC50 is 46.54 μg/mL) was found to be improved significantly over pure flutamide (IC50 is 64.63 μg/mL) against human prostate cancer PC-3 cell line whereas F-PGNPs did not show any significant toxicity up to a fairly high concentration toward normal mouse macrophage J774A.1 cells. " 01/01/2021 - "Flutamide was used to bioconjugate with PGNPs to improve its efficacy against prostate cancer. " 01/01/2021 - "Anti-androgen drug flutamide was delivered to the prostate cancer cells using Papain Mediated Synthesized Gold Nanoparticles (PGNPs) as the drug delivery system. "
3.	Breast Neoplasms (Breast Cancer) 04/01/2019 - "Moreover, the synergistic effect of DOX@BET loaded PGNPs decreased the cell viability amount of breast cancer cells (MCF-7) respect to the free form of DOX or BET which indicated that the developed smart nanocarrier will be a hopeful nanocarrier for cancer therapy."

Related Drugs and Biologics

1.	Flutamide (Eulexin)
2.	Papain
3.	Gold
4.	Androgens

Related Therapies and Procedures

1.	Therapeutics