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ICI 89406
RN given refers to parent cpd
Also Known As:
ICI 89 406; ICI 89,406; ICI-89406; urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Propanolamines: 4
ICI 89406: 4
Alcohols: 595
Amino Alcohols: 20
Propanolamines: 4
ICI 89406: 4
Propanols: 3
Propanolamines: 4
ICI 89406: 4
Related Diseases
1.
Angina Pectoris
07/01/1980 - "
These studies indicate that ICI 89,406 produces effective beta-adrenoceptor blockade during exercise in patients with angina pectoris.
"
07/01/1980 - "
Clinical, electrocardiographic, and hemodynamic effects of ICI 89,406, a new cardioselective beta-adrenoceptor antagonist with intrinsic sympathomimetic activity, in patients with angina pectoris.
"
07/01/1980 - "
ICI 89,406, a new cardioselective beta-adrenoceptor antagonist possessing marked intrinsic sympathomimetic activity, was administered (0.04 mg/kg, i.v.) to 10 patients with stable, uncomplicated, exercise-induced angina pectoris and angiographically proven coronary artery disease.
"
2.
Glioma (Gliomas)
10/01/1986 - "
A series of inhibition curves was generated with the unlabeled ligands ICI 89,406 (beta 1-selective) and ICI 118,551 (beta 2-selective), using membranes prepared from C6 glioma cells.
"
07/01/1986 - "
The selectivity of [125I]iodopindolol, [125I]iodocyanopindolol, [125I]iodohydroxybenzylpindolol and [3H]dihydroalprenolol for beta-1 and beta-2 adrenergic receptors was assessed by inhibiting the binding of each radioligand with the beta-1-selective unlabeled ligand ICI 89,406 at increasing concentrations of the radioligand, using membranes prepared from C6 glioma cells, which have both beta-1 and beta-2 adrenergic receptors.
"
3.
Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1983 - "
The hemodynamic effects of seven different beta-blockers (propranolol, atenolol, acebutolol, ICI 72,222, ICI 89,406, and pindolol) were studied at rest in patients with ischemic heart disease.
"
4.
Coronary Artery Disease (Coronary Atherosclerosis)
07/01/1980 - "
ICI 89,406, a new cardioselective beta-adrenoceptor antagonist possessing marked intrinsic sympathomimetic activity, was administered (0.04 mg/kg, i.v.) to 10 patients with stable, uncomplicated, exercise-induced angina pectoris and angiographically proven coronary artery disease.
"
Related Drugs and Biologics
1.
Adrenergic Receptors (Adrenergic Receptor)
2.
Ligands
3.
Iodocyanopindolol
4.
beta-2 Adrenergic Receptors
5.
Sympathomimetics (Sympathomimetic Amines)
6.
Propranolol (Inderal)
7.
Pindolol (LB 46)
8.
Dihydroalprenolol
9.
Atenolol (Tenormin)
10.
Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)