perfluorooctanoic acid

RN given refers to parent cpd

Also Known As:

APFO; PFOA cpd; PFOA perfluorooctanoic acid; ammonium perfluorooctanoate; pentadecafluorooctanoic acid; perfluorinated octanoic acid; perfluorooctanoate; perfluorooctanoic acid, anhydride; perfluorooctanoic acid, cesium salt; perfluorooctanoic acid, chromium (3+) salt; perfluorooctanoic acid, cobalt (2+) salt; perfluorooctanoic acid, lithium salt; perfluorooctanoic acid, monoammonium salt; perfluorooctanoic acid, monopotassium salt; perfluorooctanoic acid, monosilver (1+) salt; perfluorooctanoic acid, monosodium salt; perfluorooctanoyl chloride; potassium pentadecafluorooctanoate; potassium perfluorooctanoate; silver perfluorooctanoate; silver(1+) pentadecafluorooctanoate; sodium perfluorooctanoate

Networked: 340 relevant articles (2 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Calafat, Antonia M: 12 articles (12/2023 - 01/2015)
2.	Steenland, Kyle: 12 articles (04/2023 - 11/2012)
3.	Olsen, Geary W: 8 articles (06/2024 - 06/2009)
4.	Jiang, Qixiao: 8 articles (11/2022 - 01/2013)
5.	Winquist, Andrea: 8 articles (02/2016 - 08/2013)
6.	Longnecker, Matthew P: 7 articles (06/2024 - 06/2012)
7.	Kannan, Kurunthachalam: 7 articles (04/2024 - 11/2012)
8.	Olsen, Jørn: 7 articles (01/2020 - 07/2008)
9.	Purdue, Mark P: 6 articles (02/2024 - 01/2021)
10.	Grandjean, Philippe: 6 articles (12/2021 - 04/2014)

Related Diseases

1.	Birth Weight (Birth Weights) 04/15/2023 - "An interquartile range increase in perfluorooctanoic acid (PFOA) produced a non-significant reduction in birthweight z-score during the 1st and 2nd trimesters (β = -0.01 g [95% CI = -0.14, 0.12] and β = -0.07 g [95% CI = -0.19, 0.06], respectively) whereas the relationship was significant and positive during the 3rd trimester (β = 0.15 g; 95% CI = 0.01, 0.29). " 06/01/2009 - "Recent studies have examined the associations between perfluorooctanoic acid (PFOA) levels in cord blood and maternal plasma with lowered birth weight and gestational age in humans; however, no study has examined these effects in a population of known high PFOA exposure. " 01/01/2022 - "Prenatal Perfluorooctanoic Acid (PFOA) Exposure Is Associated With Lower Infant Birthweight Within the MADRES Pregnancy Cohort." 01/01/2020 - "We found significant inverse associations between Perfluorooctanoic Acid (PFOA) and birth weight (adjusted β = -119 g, 95% CI: -201; -36), birth length (adjusted β = -0.37 cm, 95% CI: -0.76; 0.02, borderline significant) and head circumference (adjusted β = -0.35 cm, 95% CI: -0.59; -0.10) and a positive association with GA (adjusted β = 0.45 week, 95% CI: 0.17; 0.74). " 11/01/2018 - "Serum Perfluorooctanoic Acid and Birthweight: An Updated Meta-analysis With Bias Analysis."
2.	COVID-19 01/01/2021 - "In unadjusted models, the risk of COVID-19 infection was positively associated with urinary levels of perfluorooctanesulfonic acid (PFOS) (Odds ratio: 2.29 [95% CI: 1.52-3.22]), perfluorooctanoic acid (PFOA) (2.91, [1.95-4.83], and total PFASs (∑ (12) PFASs) (3.31, [2.05-4.65]). " 06/01/2024 - "We conducted a case-control study to examine the association between COVID-19 diagnosis and PFAS serum concentrations among employees and retirees from two 3 M facilities, one of which historically generated perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS). " 01/01/2024 - "Most importantly, several drug candidates (Periodate-oxidized adenosine, Desipramine, Quercetin, Perfluoroheptanoic acid, Tetrandrine, Pentadecafluorooctanoic acid, Benzo[a]pyrene, SARIN, Dorzolamide, 8-Bromo-cAMP) may prove effective in treating ICC and COVID-19. "
3.	Neoplasms (Cancer) 03/01/2013 - "Perfluorooctanoic acid (PFOA) has been linked to cancer in occupational mortality studies and animal toxicologic research. " 03/18/2024 - "Evaluating the mode of action of perfluorooctanoic acid-induced liver tumors in male Sprague-Dawley rats using a toxicogenomic approach." 02/20/2024 - "As one legacy PFAS, perfluorooctanoic acid (PFOA) exposure correlated with various cancers and their mortality. " 02/20/2024 - "Perfluorooctanoic acid (PFOA) exposure correlated with various cancers and their mortality. " 01/01/2020 - "The most well-studied member of the PFAS class, perfluorooctanoic acid (PFOA), induces tumors in animal bioassays and has been associated with elevated risk of cancer in human populations. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2017 - "This research translates findings from biologists into messages at two literacy levels about perfluorooctanoic acid (PFOA), a possible environmental contributor to breast cancer. " 03/01/2012 - "Recent research links perfluorooctanoic acid (PFOA) to increased breast cancer risk. " 02/23/2024 - "The summary relative risks (RR) estimated by random-effects meta-analyses did not support an association between PFAS and overall breast cancer risk (e.g., a natural log (ln)-unit increase in serum/plasma concentrations [ng/mL] for perfluorooctanoate [PFOA] RR=0.95, 95% confidence interval [CI]:0.77-1.18; perfluorooctane sulfonate [PFOS] RR=0.98, 95%CI: 0.87-1.11). " 08/17/2014 - "Perfluorooctanoic acid stimulates breast cancer cells invasion and up-regulates matrix metalloproteinase-2/-9 expression mediated by activating NF-κB." 01/01/2013 - "The 3 risk factors were the roles of genetics, progesterone, and ingesting perfluorooctanoic acid in breast cancer risk. "
5.	Body Weight (Weight, Body) 05/01/2009 - "The T-cell-dependent antibody response is suppressed in mice exposed to 3.75, 7.5, 15, and 30 mg PFOA (perfluorooctanoic acid)/kg body weight (bw). " 08/15/2006 - "In Phase II, APFO doses of either 10 or 30mg/kg body weight were given to groups of 23-, 30-, and 32-day-old male and female rats, and plasma was collected at 2 and 24h after the dose (separate groups), and urine was collected for 24h. " 03/15/2006 - "Mean body weights were about 20% lower in rats and mice dosed with 30 mg/kg of linear/branched or linear APFO compared to controls, and 3-5% lower in animals dosed with 30 mg/kg of branched APFO. " 12/01/1987 - "Dietary levels of 3 ppm or greater ammonium perfluorooctanoate for either 14 or 21 days produced a significant elevation in liver weight both on an absolute and on an organ/body weight ratio basis. " 08/01/2007 - "Fate of perfluorooctanoic acid (PFOA) after an intravenous injection to male rats at the dose of 0.041 mg/kg body weight was compared with that at the dose of 16.56 mg/kg body weight. "

Related Drugs and Biologics

1.	perfluoro-n-heptanoic acid
2.	Quercetin
3.	8-Bromo Cyclic Adenosine Monophosphate (8 Bromo Cyclic Adenosine Monophosphate)
4.	Sarin
5.	Desipramine (Pertofrane)
6.	Benzo(a)pyrene
7.	dorzolamide (Trusopt)
8.	periodate-oxidized adenosine
9.	tetrandrine
10.	perfluorooctane sulfonic acid

Related Therapies and Procedures

1.	Vitreoretinal Surgery
2.	Therapeutics
3.	Immunomodulation
4.	Septal Occluder Device
5.	Secondary Prevention