delta(14)-sterol reductase

NADPH-dependent enzyme that catalyzes the formal trans addition of hydrogen across the 14,15-pi bond in 8,14-sterol dienes; forms 4,4-dimethylzymosterol in lanosterol metabolism pathway from 4,4-dimethyl-5alpha-cholesta-8,14,25-trien-3beta-ol or from 4,4-dimethyl-cholesta-8,14,24-trienol

Also Known As:

14,15-sterol reductase; 3 beta-hydroxysterol delta 14-reductase; C-14 sterol reductase; FACKEL protein, Arabidopsis; FK protein, Arabidopsis; Tm7sf2 protein, mouse; delta 14,15-reductase; delta 14-sterol reductase; delta 8,14-steroid 14-reductase; delta 8,14-sterol delta 14-reductase; ignosterol reductase; sterol C-14 reductase

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - delta(14)-sterol reductase: 1

Experts

1.	Hennekam, Raoul C M: 1 article (04/2003)
2.	Kelley, Richard I: 1 article (04/2003)
3.	Koster, Janet: 1 article (04/2003)
4.	Mooyer, Petra: 1 article (04/2003)
5.	Noort Gv, Gerard van: 1 article (04/2003)
6.	Oosterwijk, Jan C: 1 article (04/2003)
7.	Wanders, Ronald J A: 1 article (04/2003)
8.	Waterham, Hans R: 1 article (04/2003)
9.	Wilcox, William R: 1 article (04/2003)

Related Diseases

1.	HEM dysplasia 04/01/2003 - "Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene."

Related Drugs and Biologics

1.	Lamin B Receptor