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phosphoketolase

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Carbon Lyases
      - Aldehyde-Lyases: 34
        phosphoketolase: 3

Experts

1.	Bose, Indrani: 1 article (03/2015)
2.	Luckie, Taylor: 1 article (03/2015)
3.	Smith, Kerry: 1 article (03/2015)
4.	Taylor, Tonya: 1 article (03/2015)
5.	Tittmann, Kai: 1 article (12/2014)
6.	Ashida, Hisashi: 1 article (10/2010)
7.	Fushinobu, Shinya: 1 article (10/2010)
8.	Katayama, Takane: 1 article (10/2010)
9.	Kim, Byung-Jun: 1 article (10/2010)
10.	Shoun, Hirofumi: 1 article (10/2010)

Related Diseases

1.	Dehydration (Water Stress) 10/29/2010 - "The phosphoketolase reaction is different from other well studied ThDP-dependent enzymes because it involves a dehydration step. " 10/29/2010 - "Crystal structures of phosphoketolase: thiamine diphosphate-dependent dehydration mechanism." 12/01/2014 - "While transketolase catalyzes the reversible transfer of 2-carbon ketol fragments in a reaction analogous to that of transaldolase, phosphoketolase forms acetyl phosphate as final product in a reaction that comprises ketol cleavage, dehydration and phosphorolysis. "
2.	Fungal Meningitis 03/19/2015 - "The basidiomycete Cryptococcus neoformans, an invasive opportunistic pathogen of the central nervous system, is the most frequent cause of fungal meningitis worldwide resulting in more than 625,000 deaths per year worldwide. Although electroporation has been developed for the transformation of plasmids in Cryptococcus, only biolistic delivery provides an effective means to transform linear DNA that can be integrated into the genome by homologous recombination. Acetate has been shown to be a major fermentation product during cryptococcal infection, but the significance of this is not yet known. A bacterial pathway composed of the enzymes xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (Xfp) and acetate kinase (Ack) is one of three potential pathways for acetate production in C. "
3.	Infections 03/19/2015 - "The basidiomycete Cryptococcus neoformans, an invasive opportunistic pathogen of the central nervous system, is the most frequent cause of fungal meningitis worldwide resulting in more than 625,000 deaths per year worldwide. Although electroporation has been developed for the transformation of plasmids in Cryptococcus, only biolistic delivery provides an effective means to transform linear DNA that can be integrated into the genome by homologous recombination. Acetate has been shown to be a major fermentation product during cryptococcal infection, but the significance of this is not yet known. A bacterial pathway composed of the enzymes xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (Xfp) and acetate kinase (Ack) is one of three potential pathways for acetate production in C. "

Related Drugs and Biologics

1.	Enzymes
2.	Xylulose
3.	Transketolase
4.	Transaldolase
5.	Thiamine Pyrophosphate
6.	Phosphates (Orthophosphate)
7.	Fructose
8.	Acetates (Acetic Acid Esters)
9.	Acetate Kinase
10.	acetyl phosphate