oxoglutarate translocator

MW 31.5 KDa; RefSeq NM_003562 (human); NM_022398 (rat)

Also Known As:

2-ketoglutarate carrier; 2-oxoglutarate carrier; 2-oxoglutarate carrier protein, rat; OGC transport protein; SLC25A11 protein, human; oxoglutarate carrier; oxoglutarate carrier protein, human; solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 protein, human

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - oxoglutarate translocator: 4
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - oxoglutarate translocator: 4

Experts

1.	Kang, Joon Hee: 2 articles (11/2020 - 02/2019)
2.	Kim, Soo-Youl: 2 articles (11/2020 - 02/2019)
3.	Lee, Jae-Seon: 2 articles (11/2020 - 02/2019)
4.	Lee, Seon-Hyeong: 2 articles (11/2020 - 02/2019)
5.	Yook, Jong In: 2 articles (11/2020 - 02/2019)
6.	Choi, Jiwon: 1 article (11/2020)
7.	Ha, Ji Sun: 1 article (11/2020)
8.	Jang, Hyonchol: 1 article (11/2020)
9.	Kim, Hee Yeon: 1 article (11/2020)
10.	Cho, Eunae Sandra: 1 article (02/2019)

Related Diseases

1.	Neoplasms (Cancer) 11/23/2020 - "In a spontaneous lung cancer model, tumor growth was reduced by 50% in heterozygous oxoglutarate carrier (OGC) knock-out mice compared with wild-type counterparts. " 02/01/2019 - "Cancer cells critically depended on the oxoglutarate carrier SLC25A11 for transporting NADH from cytosol to mitochondria as a malate form for the purpose of ATP production. " 02/01/2019 - "We have proposed that the oxoglutarate carrier SLC25A11 is important for ATP production in cancer by NADH transportation from the cytosol to mitochondria as a malate. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 12/19/2022 - "New Insights Regarding Hemin Inhibition of the Purified Rat Brain 2-Oxoglutarate Carrier and Relationships with Mitochondrial Dysfunction."
3.	Melanoma (Melanoma, Malignant) 11/23/2020 - "Oxoglutarate Carrier Inhibition Reduced Melanoma Growth and Invasion by Reducing ATP Production."
4.	Lung Neoplasms (Lung Cancer) 11/23/2020 - "In a spontaneous lung cancer model, tumor growth was reduced by 50% in heterozygous oxoglutarate carrier (OGC) knock-out mice compared with wild-type counterparts. "
5.	Liver Neoplasms (Liver Cancer) 01/01/2018 - "The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	NAD (NADH)
3.	Hemin (Panhematin)
4.	Cholesterol
5.	malic acid (malate)