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mercuric reductase
reduces Hg2+ to volatile Hg, contains FAD, requires NADPH
Also Known As:
MerA protein, E coli
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Oxidoreductases: 13671
mercuric reductase: 4
Experts
1.
Aziz, Ramy K
: 1 article (01/2019)
2.
El Hosseiny, Ahmed
: 1 article (01/2019)
3.
Maged, Mohamad
: 1 article (01/2019)
4.
Ramadan, Eman
: 1 article (01/2019)
5.
Saadeldin, Mona Kamal
: 1 article (01/2019)
Related Diseases
1.
Poisoning
01/01/2019 - "
To the best of our knowledge, this study is the first to rationally design a mercuric reductase with enhanced thermal stability, which we propose to have a strong potential in the bioremediation of mercurial poisoning.IMPORTANCE The Red Sea is an attractive environment for bioprospecting.
"
01/01/2019 - "
Mercuric reductase enzymes functional in such extreme conditions could be considered a potential tool in the environmental detoxification of mercurial poisoning and might alleviate ecological hazards in the mining industry.
"
2.
Hypersensitivity (Allergy)
04/01/1995 - "
One recombinant plasmid (pMRA17) inducibly encoded a typical broad-spectrum mercurial resistance, whereas the other recombinant plasmid (pMRB01) constitutively conferred hypersensitivity to phenylmercury in the absence of mercuric reductase activity.
"
10/01/1979 - "
A mutant of plasmid R100-1, which conferred cellular hypersensitivity to Hg2+ because of the insertion of Tn801 (TnA) into the gene determining synthesis of mercuric reductase enzyme, allowed further mutational events to be selected which resulted in either reversion to Hg2+ resistance (characteristic plasmid R100-1) or sensitivity at a level characteristic of plasmidless strains.
"
3.
Starvation
01/01/2023 - "
Proteins overrepresented in the presence of cyanide and mercury included mercury transporters, mercuric reductase MerA, transcriptional regulator MerD, arsenate reductase and arsenical resistance proteins, thioredoxin reductase, glutathione S-transferase, proteins related to aliphatic sulfonates metabolism and sulfate transport, hemin import transporter, and phosphate starvation induced protein PhoH, among others.
"
Related Drugs and Biologics
1.
Enzymes
2.
Arsenate Reductases (Arsenate Reductase (Azurin))
3.
Thioredoxin-Disulfide Reductase
4.
Sulfates (Sulfates, Inorganic)
5.
Proteins (Proteins, Gene)
6.
Phosphates (Orthophosphate)
7.
Mercury
8.
Hemin (Panhematin)
9.
Glutathione Transferase (Glutathione S-Transferase)
10.
Cyanides (Isocyanides)