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aspartate 4-decarboxylase

Also Known As:

aminomalonate decarboxylase; aspartate beta-decarboxylase; aspartate decarboxylase

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Carbon Lyases
      - Carboxy-Lyases: 620
        aspartate 4-decarboxylase: 3

Experts

1.	Arima, Takeshi: 1 article (01/2019)
2.	Kato, Norihisa: 1 article (01/2019)
3.	Kumrungsee, Thanutchaporn: 1 article (01/2019)
4.	Nirmagustina, Dwi Eva: 1 article (01/2019)
5.	Onishi, Kai: 1 article (01/2019)
6.	Sato, Kanako: 1 article (01/2019)
7.	Yanaka, Noriyuki: 1 article (01/2019)
8.	Dartois, Véronique: 1 article (11/2017)
9.	Dick, Thomas: 1 article (11/2017)
10.	Gopal, Pooja: 1 article (11/2017)

Related Diseases

1.	Tuberculosis (Tuberculoses) 04/25/2016 - "It is known that panD gene encodes aspartate decarboxylase essential for β-alanine synthesis that makes it a potential therapeutic drug target for tuberculosis treatment. " 11/10/2017 - "Previously, we showed that a major in vitro and in vivo mechanism of resistance to pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug pyrazinamide (PZA), involves missense mutations in the aspartate decarboxylase PanD, an enzyme required for coenzyme A biosynthesis. "
2.	Vitamin B 6 Deficiency (Pyridoxine Deficiency) 01/01/2019 - "Vitamin B6 deficiency significantly attenuated the activity of heart tissue glutamate decarboxylase (GAD), although there was undetectable activity of aspartate decarboxylase (ADC), suggesting that the involvement of vitamin B6 in imidazole metabolite synthesis occurs partly through GABA production by regulating GAD rather than through a straightforward β-alanine production pathway via ADC in the heart. "

Related Drugs and Biologics

1.	Alanine (L-Alanine)
2.	Vitamin B 6
3.	Pyrazinamide
4.	Prodrugs
5.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
6.	gamma-Aminobutyric Acid (GABA)
7.	Enzymes
8.	Coenzyme A (CoA)
9.	imidazole
10.	pyrazinoic acid