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cinromide
Also Known As:
3-bromo-N-ethylcinnamide; cinromide, (E)-isomer; 3-(3-bromophenyl)-N-ethyl-2-propenamide
Networked:
9
relevant articles (
2
outcomes,
4
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Carbocyclic Acids
Cinnamates: 48
cinromide: 9
Experts
1.
Brigo, Francesco
: 1 article (01/2021)
2.
Eltze, Christin
: 1 article (01/2021)
3.
Jones, Katherine
: 1 article (01/2021)
4.
Matricardi, Sara
: 1 article (01/2021)
Related Diseases
1.
Seizures (Absence Seizure)
03/01/1982 - "
These data suggest that cinromide should be clinically effective, not only against tonic-clonic seizures, but also, toxicity permitting, against complex partial attacks as well.
"
01/01/2021 - "
We found very low-certainty evidence that 35 more people per 1000 (CI 123 fewer to 434 more) had 50% or greater average reduction of overall seizures with add-on cinromide compared to add-on placebo (one study; 56 participants; RR 1.15, 95% CI 0.47 to 2.86).
"
08/01/1983 - "
This study did not demonstrate a beneficial effect of cinromide over placebo for Type A, B, or C partial seizures.
"
01/01/1988 - "
Cinromide was also able to suppress this type of seizures, but in adult rats the dose of 75 mg.kg-1 had to be administered because even the 50 mg.kg-1 dose was not sufficient.
"
01/01/1988 - "
Cinromide was efficient against this type of seizures at all developmental stages, but its action in 7- and especially in 12-day-old rat pups was less marked than in older animals.
"
2.
Lennox Gastaut Syndrome
07/01/1989 - "
This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome.
"
07/01/1989 - "
The Group for the Evaluation of Cinromide in the Lennox-Gastaut Syndrome.
"
07/01/1989 - "
Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut Syndrome.
"
3.
Drug Resistant Epilepsy
08/01/1983 - "
A double-blind controlled trial of cinromide in 25 adult subjects with refractory epilepsy using the maximum tolerated dose showed that it possessed no significant antiepileptic properties.
"
4.
Epilepsy (Aura)
08/01/1983 - "
Cinromide in epilepsy: a pilot study.
"
08/01/1983 - "
Cinromide has previously been shown to have significant antiepileptic activity in various animal models of epilepsy.
"
5.
Partial Epilepsies (Epilepsy, Partial)
08/01/1983 - "
Monotherapy with the experimental antiepileptic drug cinromide was evaluated in 11 adult outpatients with uncontrolled partial epilepsy.
"
Related Drugs and Biologics
1.
Anticonvulsants (Antiepileptic Drugs)
2.
Vigabatrin
3.
Valproic Acid (Depakote)
4.
Taurine
5.
Carbamazepine (Tegretol)
6.
Amphetamine (Amfetamine)
7.
Amantadine (Aman)
8.
Allopurinol (Remid)
9.
Pentylenetetrazole (Metrazol)
Related Therapies and Procedures
1.
Therapeutics