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ozolinone
active metabolite of etozolin; RN refers to (Z)-isomer; structure in first source
Also Known As:
3-methyl-4-oxo-5-piperidinothiazolidine-2-ylidine acetic acid; ozolinone, (Z)-(+)-isomer; ozolinone, (Z)-(-)-isomer
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
ozolinone: 4
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
ozolinone: 4
Related Diseases
1.
Renal Insufficiency (Renal Failure)
01/01/1980 - "
It is concluded that in the single dose experiments renal insufficiency does not significantly influence the metabolization of etozolin and ozolinone.
"
01/01/1980 - "
Even in severe renal insufficiency the HL of etozolin and ozolinone did not differ from normal values, the mean HL of etozolin being 2.8 +/- 0.4 h and of ozolinone being 10.2 +/- 1.5 h.
"
2.
Liver Cirrhosis (Hepatic Cirrhosis)
12/01/1987 - "
The results suggest that acute hepatitis and hepatic cirrhosis lead to a reduced formation of ozolinone.
"
12/01/1987 - "
The single dose kinetics of (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin) and its active metabolite ozolinone were determined in 6 healthy volunteers, in 12 patients with acute hepatitis and in 15 patients with hepatic cirrhosis with ascites.
"
12/01/1987 - "
Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites.
"
3.
Kidney Diseases (Kidney Disease)
01/01/1980 - "
The lack of correlation between elimination half-life (HL) and creatinine clearance showed that there is no influence of kidney disease on the pharmacokinetic parameters of etozolin and ozolinone.
"
4.
Hypertension (High Blood Pressure)
01/01/1982 - "
The low placental and fetal concentrations of etozolin and ozolinone suggest that these drugs may prove useful when a diuretic is indicated in the treatment of oedema and hypertension during pregnancy.
"
5.
Hepatitis
12/01/1987 - "
The results suggest that acute hepatitis and hepatic cirrhosis lead to a reduced formation of ozolinone.
"
12/01/1987 - "
In cirrhosis, the plasma level time curves of etozolin and ozolinone differed significantly from the controls and also from those of the patients with acute hepatitis.
"
12/01/1987 - "
The single dose kinetics of (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin) and its active metabolite ozolinone were determined in 6 healthy volunteers, in 12 patients with acute hepatitis and in 15 patients with hepatic cirrhosis with ascites.
"
12/01/1987 - "
Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites.
"
Related Drugs and Biologics
1.
etozolin
2.
Furosemide (Lasix)
3.
Diuretics
4.
Creatinine
5.
Bumetanide (Bumex)
6.
azosemide
7.
piretanide