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methyl 2-tetradecylglycidate
structure
Also Known As:
McN 3716; McN-3716; methyl 2-tetradecyloxiranecarboxylate; methyl palmoxirate
Networked:
8
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Propionates: 988
methyl 2-tetradecylglycidate: 8
Ethers: 242
Cyclic Ethers: 12
Epoxy Compounds: 689
methyl 2-tetradecylglycidate: 8
Lipids: 114793
Fatty Acids: 27405
Volatile Fatty Acids: 3052
Propionates: 988
methyl 2-tetradecylglycidate: 8
Related Diseases
1.
Ketosis
07/01/1984 - "
Treatment with methyl palmoxirate protected against the development of exercise-induced ketosis.
"
10/01/1978 - "
Thus, McN-3716 may have potential utility as an oral therapeutic agent for the treatment of ketosis-prone juvenile or maturity-onset diabetes.
"
02/01/1985 - "
The oral hypoglycemic agent, methyl 2-tetradecylglycidate (Me-TDGA), which inhibits in vitro mitochondrial carnitine palmitoyl transferase A (CPT-A) was used to study the relationship of CPT inhibition to changes in ketonemia and glycemia in normal and diabetic rats.
"
02/01/1985 - "
Inhibition of mitochondrial carnitine palmitoyl transferase A in vivo with methyl 2-tetradecylglycidate (methyl palmoxirate) and its relationship to ketonemia and glycemia.
"
2.
Hypoglycemia (Reactive Hypoglycemia)
09/01/1989 - "
Recovery from insulin-induced hypoglycemia (nadirs of 58 +/- 5 and 42 +/- 4 mg/dl in the vehicle- and methyl palmoxirate-treated groups, respectively) was not significantly different between the two groups of dogs.
"
09/01/1989 - "
with vehicle or methyl palmoxirate (2.5 mg/kg/day X 7 days) to recover from insulin-induced hypoglycemia.
"
09/01/1989 - "
Plasma glucagon levels increased in both vehicle- and methyl palmoxirate-treated dogs in response to hypoglycemia, indicating that release of an important counter-regulatory hormone was not compromised by drug treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
"
09/01/1989 - "
Effect of the fatty acid oxidation inhibitor methyl palmoxirate (methyl 2-tetradecylglycidate) on recovery from insulin-induced hypoglycemia in diabetic dogs.
"
10/01/1978 - "
Furthermore, evidence is presented that McN-3716 produces hypoglycemia by a mechanism which differs from that of other oral hypoglycemic agents, the biguanides and the sulfonylureas.
"
3.
Weight Gain
03/30/1988 - "
Weight gain (mid- and high-dosage group) and survivability (high-dosage group) were significantly (p less than or equal to 0.05) reduced in offspring of methyl palmoxirate-treated dams as compared to control offspring.
"
4.
Lordosis
03/01/1993 - "
Treatment with an inhibitor of glycolysis (2-deoxy-D-glucose) in combination with an inhibitor of fatty acid oxidation (methyl palmoxirate) for 48 h mimicked the effects of food deprivation and suppressed the amount of time spent in lordosis after treatment with EB+P.
"
5.
Hyperinsulinism (Hyperinsulinemia)
10/01/1993 - "
Methyl palmoxirate stimulated glucose uptake in heart in 24-h fasted animals [15 +/- 5 vs. 220 +/- 28 (SE) mumol x 100 g-1 x min-1], with smaller effects in 5-h fasted animals with or without hyperinsulinemia.
"
10/01/1993 - "
Fasted animals [5 h with or without hyperinsulinemia (100 mU/l) and 24 h] received methyl palmoxirate (30 or 100 mg/kg body wt po) or vehicle 30 min before a euglycemic glucose clamp.
"
10/01/1993 - "
Methyl palmoxirate induced significant activation of pyruvate dehydrogenase in heart in the basal state, but not during hyperinsulinemia.
"
10/01/1993 - "
In skeletal muscles, methyl palmoxirate suppressed glucose utilization in the basal state but had no effect during hyperinsulinemia; pyruvate dehydrogenase activation in skeletal muscle was not affected by methyl palmoxirate under any conditions.
"
Related Drugs and Biologics
1.
Hypoglycemic Agents (Hypoglycemics)
2.
Transferases
3.
Carnitine (L-Carnitine)
4.
2- cyclohexylidenhydrazo- 4- phenyl- thiazole
5.
Glucose (Dextrose)
6.
Fatty Acids (Saturated Fatty Acids)
7.
methyl 2-tetradecylglycidate
8.
Pyruvic Acid (Pyruvate)
9.
Oxidoreductases (Dehydrogenase)
10.
Insulin (Novolin)
Related Therapies and Procedures
1.
Aftercare (After-Treatment)