HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ruthenocene

member of metallocene group; they contain two cyclopentadiene rings bound strongly to metal atom, in this case ruthenium

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - ruthenocene: 5

Experts

1.	Alborzinia, Hamed: 1 article (02/2015)
2.	Gross, Annika: 1 article (02/2015)
3.	Martin, Lisandra L: 1 article (02/2015)
4.	Metzler-Nolte, Nils: 1 article (02/2015)
5.	Piantavigna, Stefania: 1 article (02/2015)
6.	Wölfl, Stefan: 1 article (02/2015)
7.	Kemp, K Christian: 1 article (07/2012)
8.	Nell, Margo J: 1 article (07/2012)
9.	Swarts, Jannie C: 1 article (07/2012)
10.	VAN Rensburg, Constance E J: 1 article (07/2012)

Related Diseases

1.	Carcinoma (Carcinomatosis) 07/01/2012 - "The ruthenocene-containing β-diketones RcCOCH(2)COR where Rc=Ru(II)(C(5)H(5))(C(5)H(4)) and R=CF(3) (1), CH(3) (2), Ph=C(6)H(5) (3) and Fc=Fe(II)(C(5)H(5))(C(5)H(4)) (4) were tested for cytotoxicity against HeLa (human cervix epithelioid) cancer, COR L23 (human large cell lung carcinoma) and the platinum-resistant CoLo 320DM (human colorectal) and COR L23/CPR cancer cell lines. " 01/01/1985 - "Estradiol is competetively inhibiting the retention of acetyl-ruthenocene by the kidneys, the same effect also being obtained by tamoxifen, an anti-estrogen used clinically for regression of mammary carcinoma. "
2.	Neoplasms (Cancer) 07/01/2012 - "The ruthenocene-containing β-diketones RcCOCH(2)COR where Rc=Ru(II)(C(5)H(5))(C(5)H(4)) and R=CF(3) (1), CH(3) (2), Ph=C(6)H(5) (3) and Fc=Fe(II)(C(5)H(5))(C(5)H(4)) (4) were tested for cytotoxicity against HeLa (human cervix epithelioid) cancer, COR L23 (human large cell lung carcinoma) and the platinum-resistant CoLo 320DM (human colorectal) and COR L23/CPR cancer cell lines. "
3.	Necrosis 02/01/2015 - "While most cells remain viable even at 300 μM of the metal free bioconjugate 1, most cells are dead or in late stages of apoptosis at 200 μM of the ruthenocene derivative 3, and at 100 μM of the most active ferrocene derivative 2, however, all show very little sign of necrosis. "
4.	Leukemia 09/22/2011 - "A new illudin M lactone 5 was of low anticancer activity, but its ruthenocene diester 6b also reached single-digit micromolar IC(50) (72 h) values in HCT-116, MCF-7, and HL-60 leukemia cells while not affecting HF. "
5.	Breast Neoplasms (Breast Cancer) 04/21/2005 - "A series of ruthenocene derivatives, 1-[4-(O(CH(2))(n)()N(CH(3))(2))phenyl]-1-(4-hydroxyphenyl)-2-ruthenocenylbut-1-ene, with n = 2-5, based on the structure of the breast cancer drug tamoxifen has been prepared. " 04/21/2005 - "Ruthenocene derivatives act as anti-estrogens as effective (n = 2) or slightly more effective (n = 3-5) than hydroxytamoxifen on ERalpha-positive breast cancer cell lines but, unlike ferrocifens, do not show antiproliferative effects on ERalpha-negative breast cancer cell lines. "

Related Drugs and Biologics

1.	Tamoxifen
2.	Estrogens (Estrogen)
3.	Estrogen Receptor alpha
4.	Platinum
5.	Metals
6.	Lactones
7.	Estradiol (Delestrogen)
8.	illudin M
9.	afimoxifene (hydroxytamoxifen)
10.	ferrocene

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)