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ethynerone
Also Known As:
17-alpha-chloroethynyl-19-nor-4,9-androstadien-17-beta-ol-3-one; 19-nor-17-alpha-pregna-4,9-dien-20-yn-3-one, 21-chloro-17-hydroxy-; 21-chloro-17-hydroxy-19-nor-17 alpha-pregna-4,9-dien- 20-yn-3-one
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Norsteroids: 16
Norpregnanes: 2
Norpregnadienes
ethynerone: 4
Related Diseases
1.
Neoplasms (Cancer)
07/01/1980 - "
Malignant tumors were not seen in 33 dogs administered mestranol at 0.02 and 0.05 mg/kg/day for 7 years or in 18 dogs given ethynerone without mestranol at 1.00 mg/kg/day for 5 years.
"
05/01/1988 - "
The mestranol and ethynerone combination produced a proliferative atypia in 22 of 52 animals (42%), including five identical to intraductal carcinoma in the human and one identical to lobular neoplasia.
"
07/01/1980 - "
The malignant tumors were observed in 1 dog that received ethynerone plus mestranol at 1.05 mg/kg/day and in 4 dogs that received chlorethynyl norgestrel plus mestranol at 1.05 mg/kg/day.
"
09/01/1977 - "
A small number of dogs that received each progestogen-mestranol combination developed clinically malignant tumors; control dogs or dogs that received only mestranol or ethynerone were unaffected.
"
06/01/1978 - "
Malignant neoplasms were seen in dogs given 10 and 25 times the proposed human dosage of anagestone acetate plus mestranol and 25 times the proposed human dosage of WY-4355 plus mestranol and ethynerone plus mestranol.
"
2.
Fibrosarcoma
07/01/1980 - "
Three dogs had single malignant mammary nodules, 3 dogs had 2 malignant nodules, 2 dogs had 4-6 malignant nodules, and 1 dog in the treatment group given high dosages of ethynerone plus mestranol had 14 mammary nodules composed of fibrosarcoma.
"
3.
Diabetes Mellitus
09/01/1977 - "
Diabetes mellitus occurred in 10 dogs from the chloroethynyl norgestrel-mestranol and anagestone acetate-mestranol groups and in 3 monkeys from the ethynerone-mestranol high dose and anagestone acetate-mestranol high dose groups.
"
4.
Noninfiltrating Intraductal Carcinoma (DCIS)
05/01/1988 - "
Eleven of 15 monkeys (73%) administered ethynerone developed proliferative atypia, ranging in degree from minimal to severe, including one invasive carcinoma and 2 lesions resembling intraductal carcinoma in the human.
"
05/01/1988 - "
The mestranol and ethynerone combination produced a proliferative atypia in 22 of 52 animals (42%), including five identical to intraductal carcinoma in the human and one identical to lobular neoplasia.
"
5.
Carcinoma (Carcinomatosis)
05/01/1988 - "
Eleven of 15 monkeys (73%) administered ethynerone developed proliferative atypia, ranging in degree from minimal to severe, including one invasive carcinoma and 2 lesions resembling intraductal carcinoma in the human.
"
Related Drugs and Biologics
1.
Mestranol
2.
Acetates (Acetic Acid Esters)
3.
anagestone
4.
chloroethynyl norgestrel
5.
Progestins (Progestagens)
6.
Norgestrel (DL-Norgestrel)