arsenite

02/15/2017 - "However, recent clinical trials revealed that arsenite is not always effective for non-APL malignancies. "
06/01/1997 - "This finding may help to explain why rodents do not develop tumors after exposure to arsenite, while humans do. "
01/01/2023 - "In the current study, we show that there is a strong induction of ISG20L1 (also known as AEN) expression in several cancer cell lines under exposure of arsenite and other chemotherapeutic agents. "
12/15/2020 - "Then, we discuss our recent studies regarding paternal inheritance of the tumor-augmenting effects in F2 mice by gestational arsenite exposure, in which we investigated alterations of DNA methylation status in F2 tumors and causative F1 sperm. "
12/01/2020 - "In this study, we focused on whether cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to tumor formation in C3H mice, and whether gestational arsenite exposure augments hepatic tumors through enhancement of cellular senescence. "

11/01/2000 - "Arsenite treatment has been found to induce clinical remission in patients with acute promyelocytic leukemia. "
12/01/2006 - "Although inorganic arsenite (As(III)) is toxic in humans, it has recently emerged as an effective chemotherapeutic agent for acute promyelocytic leukemia (APL). "
01/01/2016 - "Although arsenic trioxide (arsenite, As(III)) has shown a remarkable efficacy in the treatment of acute promyelocytic leukemia patients, multidrug resistance is still a major concern for its clinical use. "
07/01/2015 - "Delphinidin induces cytotoxicity and potentiates cytocidal effect in combination with arsenite in an acute promyelocytic leukemia NB4 cell line."
01/15/2015 - "Dose-dependent effects of selenite (Se(4+)) on arsenite (As(3+))-induced apoptosis and differentiation in acute promyelocytic leukemia cells."

01/01/2017 - "This study expands our understanding of arsenite's role in DNA repair inhibition and co-carcinogenesis."
01/01/2016 - "The present study addressed the effects of gestational arsenite exposure on tumorigenesis of the F2 males in C3H mice. "
12/15/2015 - "Thus, this study clarifies the role of autophagy in arsenite-induced urothelial carcinogenesis. "
01/15/2002 - "The present study was conducted to evaluate whether arsenite or its metabolite, DMA, could initiate carcinogenesis via mutagenic DNA lesions in vivo that can be attributed to oxidative damage. "
09/01/2001 - "Thus the study of chemopreventive compounds that inhibit arsenite-induced toxicity and carcinogenesis is very valuable. "

12/01/2007 - "Our data indicate that NAC is potentially therapeutic for arsenite-induced peripheral neuropathy."
04/15/2008 - "Glial-cell-derived neurotrophic factor appears to be protective against arsenite-induced peripheral neuropathy."
01/01/2009 - "Our data suggest that melatonin is potentially a therapy for arsenite-induced peripheral neuropathy."

04/15/2010 - "In this study, we have disclosed that arsenite effectively induces the apoptotic response in the HepG2 human hepatoma cells by triggering GADD45alpha induction and the subsequent activation of JNKs/AP-1 cell death pathway. "
01/01/2021 - "MicroRNA-15b in extracellular vesicles from arsenite-treated macrophages promotes the progression of hepatocellular carcinomas by blocking the LATS1-mediated Hippo pathway."
11/16/2020 - "IKKα triggers its own degradation, as a feedback loop, by activating p53-dependent autophagy, and therefore contributes substantially to hepatoma cell apoptosis induced by arsenite. "
04/26/2019 - "Herein, we reported arsenite-loaded multifunctional nanoparticles that are capable of pH-responsive ATO release for treating hepatocellular carcinoma (HCC) and real-time monitoring via magnetic resonance imaging. "
04/26/2019 - "Targeted arsenite-loaded magnetic multifunctional nanoparticles for treatment of hepatocellular carcinoma."