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N-hydroxy-4-aminobiphenyl
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Biphenyl Compounds: 7
Aminobiphenyl Compounds
N-hydroxy-4-aminobiphenyl: 4
Related Diseases
1.
Carcinogenesis
02/01/1981 - "
This unexpected high incidence of sarcomas, not previously observed in HTB-carcinogenesis model, suggested that the glucuronide conjugate of N-hydroxy-4-aminobiphenyl is a locally active carcinogen to mesenchymal cells.
"
03/15/1992 - "
The mutagenic potentials of the human bladder carcinogen 4-amino-biphenyl (ABP) and three of its proximate carcinogenic metabolites, N-hydroxy-4-aminobiphenyl (N-OH-ABP), N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and N-acetoxy-4-acetylaminobiphenyl (N-OAc-AABP) were tested on a prime human target cell type for carcinogenesis, human uroepithelial cells (HUC).
"
2.
Sarcoma (Soft Tissue Sarcoma)
02/01/1981 - "
Development of sarcomas in heterotopically transplanted rat urinary bladder unit exposed to glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl.
"
02/01/1981 - "
This unexpected high incidence of sarcomas, not previously observed in HTB-carcinogenesis model, suggested that the glucuronide conjugate of N-hydroxy-4-aminobiphenyl is a locally active carcinogen to mesenchymal cells.
"
3.
Neoplasms (Cancer)
11/01/1981 - "
Intraperitoneal injection of the N-formyl, N-acetyl, or N-propionyl derivatives of N-hydroxy-4-aminobiphenyl, N-hydroxy-2-acetylaminofluorene, or N-(4-biphenyl)glycolamide disclosed that the ability of these compounds to induce mammary tumors in the female CD rat was greater if the compound was able to be metabolized to a reactive product by one of two soluble enzymes obtained from both the liver and mammary gland.
"
4.
Neoplastic Cell Transformation
04/01/1996 - "
The tumorigenic transformation of certain occupationally significant chemicals, such as N-hydroxy-4-4'-methylenebis[2-chloroaniline] (N-OH-MOCA), N-hydroxy-ortho-toluidine (N-OH-OT), 2-phenyl-1,4-benzoquinone (PBQ) and N-hydroxy-4-aminobiphenyl (N-OH-ABP) were tested in vitro using the well established SV40-immortalized human uroepithelial cell line SV-HUC.PC.
"
Related Drugs and Biologics
1.
Carcinogens
2.
hydroxide ion
3.
Glucuronic Acid (Glucuronate)
4.
Glucuronides
5.
Enzymes
6.
4-trifluoromethylsalicylic acid (HTB)
7.
2-toluidine (o-toluidine)
8.
N-acetoxy-4-acetylaminobiphenyl
9.
N-hydroxy-4-acetylaminobiphenyl
Related Therapies and Procedures
1.
Intraperitoneal Injections