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ebericol

RN given refers to the unlabeled compound

Also Known As:

24-methylenelanost-8-en-3 beta-ol; ebericol, (14)C-labeled; eburicol; euphorbol; 24-methylene-24,25-dihydrolanosterol

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bertrand, Samuel: 1 article (06/2019)
2.	Couzinet-Mossion, Aurélie: 1 article (06/2019)
3.	Dos Santos Dias, Ana Camila: 1 article (06/2019)
4.	Etahiri, Samira: 1 article (06/2019)
5.	Lakhdar, Fatima: 1 article (06/2019)
6.	Nazih, El-Hassane: 1 article (06/2019)
7.	Ory, Lucie: 1 article (06/2019)
8.	Pouchus, Yves François: 1 article (06/2019)
9.	Roussakis, Christos: 1 article (06/2019)
10.	Ruiz, Nicolas: 1 article (06/2019)

Related Diseases

1.	Neoplasms (Cancer) 06/21/2019 - "After purification and structural identification by NMR, eburicol was assessed against four cancer cell lines, MCF-7, MDA-MB-231, NSCLC-N6-L16 and A549, and seven human pathogenic bacteria Staphylococcus aureus, Bacillus sp., Bacillus cereus, Listeria ivanovii, Escherichia coli, Citrobacter freundii and Salmonella spp. The most significant activity was cytotoxicity against MCF-7 cells (2 µM). "
2.	Infections 01/01/2019 - "Mutations in hmg1 were also shown to lead to the accumulation of ergosterol precursors, such as eburicol, by sterol profiling, while not altering the expression of sterol-demethylase genes.IMPORTANCEAspergillus fumigatus is the predominant pathogen of invasive aspergillosis, a disease state credited with over 200,000 life-threatening infections annually. "
3.	Aspergillosis 01/01/2019 - "Mutations in hmg1 were also shown to lead to the accumulation of ergosterol precursors, such as eburicol, by sterol profiling, while not altering the expression of sterol-demethylase genes.IMPORTANCEAspergillus fumigatus is the predominant pathogen of invasive aspergillosis, a disease state credited with over 200,000 life-threatening infections annually. "
4.	Arthritis (Polyarthritis) 04/24/2023 - "The contents of euphol and euphorbol in TTE were 47.03% and 18.77% respectively, and the maximal feasible dose of TTE in mice is 12 g/kg. The experimental results showed that arthritis indicators in rats deteriorated after FCA inducement compared with the control group. "

Related Drugs and Biologics

1.	HMGB1 Protein (HMG1)
2.	Sterols
3.	Ergosterol (Lumisterol)
4.	euphol