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N-n-butyl-N-nitrosourethane (BNUR)
structure
Also Known As:
BNUR
; N-butyl-N-nitrosourethan; N-butyl-N-nitrosourethane
Networked:
4
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Carbamates: 945
Urethane: 2067
Nitrosomethylurethane: 7
N-n-butyl-N-nitrosourethane: 4
Nitroso Compounds: 446
Nitrosomethylurethane: 7
N-n-butyl-N-nitrosourethane: 4
Related Diseases
1.
Neoplasms (Cancer)
03/01/1978 - "
Studies on N-butyl-N-nitrosourethan-induced cancers of the esophagus and the forestomach of rats.
"
04/01/1976 - "
Studies were made on the induction of tumors in mice by N-butyl-N-nitro-sourethan (BNUR), with the following results.
"
12/01/1980 - "
A few neurogenic tumors were induced in the offspring of mother rats that had received BNUR at the late stage of pregnancy and in the animals that had received one subcutaneous injection of BNUR within 24 hr after birth.
"
04/01/1976 - "
2) No skin tumors developed when 0.1%, 0.5%, or 1% BNUR in acetone was painted on the skin on the back of CDF1 mice three times a week for 25 weeks.
"
06/01/1974 - "
Induction of tumors of the forestomach, esophagus, pharynx, and oral cavity of the Donryu rat given N-butyl-N-nitrosourethan in the drinking water.
"
2.
Sarcoma (Soft Tissue Sarcoma)
04/01/1976 - "
3) No sarcomas developed within 30 weeks when a dose of 10, 60, or 120 mg/ml of BNUR in dimethyl sulfoxide solution was injected subcutaneously into the back of CDF1 mice, 10 times at 1-week intervals.
"
3.
Papilloma (Papillomatosis)
04/01/1976 - "
1) Oral administration of 0.04% BNUR in deionized water to CDF1 mice for 20 weeks produced papillomas in the esophagus and forestomach of all 58 mice, and 24 of the mice had squamous cell carcinoma.
"
4.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
04/01/1976 - "
1) Oral administration of 0.04% BNUR in deionized water to CDF1 mice for 20 weeks produced papillomas in the esophagus and forestomach of all 58 mice, and 24 of the mice had squamous cell carcinoma.
"
Related Drugs and Biologics
1.
Drinking Water
2.
Solutions
3.
Dimethyl Sulfoxide (DMSO)
4.
Acetone
Related Therapies and Procedures
1.
Subcutaneous Injections
2.
Oral Administration