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ciclazindol
highly selective inhibitor of noradrenaline uptake; RN given refers to parent cpd; structure
Also Known As:
10-(m-chlorophenyl)-2,3,4,10-tetrahydropyrimidol(1,2-a)indole-10-ol hydrochloride; Wy 23409
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
ciclazindol: 5
Related Diseases
1.
Weight Gain
06/01/1983 - "
Administration of 3.4 and 11 mg/kg/day of ciclazindol depressed weight gain and caused a substantial (42%) reduction in body energy gain.
"
01/01/1979 - "
The interesting observation was made that only one-third of ciclazindol patients gained weight compared to almost three-quarters of the amitriptyline group and the mean weight gain of the latter was over double that of the ciclazindol group.
"
2.
Mydriasis
05/01/1985 - "
Methoxamine-evoked mydriasis and tyramine-evoked mydriasis were antagonized by both ciclazindol and desipramine.
"
3.
Miosis
05/01/1985 - "
Pilocarpine-evoked miosis was potentiated by both ciclazindol and desipramine.
"
4.
Weight Loss (Weight Reduction)
01/01/1984 - "
Ciclazindol, a noradrenaline (NA) uptake inhibitor originally introduced as an antidepressant, has recently been shown to produce weight loss in experimental animals and patients.
"
01/01/1984 - "
Unlike CNS-stimulant anti-obesity drugs, such as amphetamine, ciclazindol may induce weight loss in animals by stimulating thermogenesis in brown adipose tissue (BAT), and it is known to stimulate resting metabolic rate (RMR) of rats and depress energetic efficiency.
"
5.
Obesity
11/01/1981 - "
5 These findings suggest that ciclazindol may produce an energy wasting effect in rodents without causing overt CNS stimulation; the implications of these findings in terms of human obesity are discussed.
"
Related Drugs and Biologics
1.
Anti-Obesity Agents (Antiobesity Drugs)
2.
Tyramine
3.
Pilocarpine (Ocusert)
4.
Norepinephrine (Noradrenaline)
5.
Methoxamine (Methoxamine Hydrochloride)
6.
Desipramine (Pertofrane)
7.
Antidepressive Agents (Antidepressants)
8.
Central Nervous System Stimulants
9.
Amphetamine (Amfetamine)
10.
Amitriptyline (Elavil)