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aflatoxin B1-2,3-oxide
Also Known As:
AFB epoxide; AFB1-2,3-oxide; aflatoxin B1-8,9-epoxide; Cyclopent(c)oxireno(4',5')furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,10-dione, 2,3,6a,7a,8a,8b-hexahydro-4-methoxy-
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Aflatoxins: 1770
Aflatoxin B1: 1058
aflatoxin B1-2,3-oxide: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Aflatoxins: 1770
Aflatoxin B1: 1058
aflatoxin B1-2,3-oxide: 3
Biological Factors: 2472
Biological Toxins: 20
Mycotoxins: 1745
Aflatoxins: 1770
Aflatoxin B1: 1058
aflatoxin B1-2,3-oxide: 3
Related Diseases
1.
Chronic Hepatitis (Chronic Active Hepatitis)
11/14/1997 - "
Metabolic activation of aflatoxin B1 to aflatoxin B1-8,9-epoxide in woodchucks undergoing chronic active hepatitis.
"
11/14/1997 - "
In the present study, we have tested the hypothesis that the metabolic activation of aflatoxin B1 to aflatoxin B1-8,9-epoxide, the ultimate mutagenic and carcinogenic mycotoxin metabolite, is enhanced in an experimental model of chronic hepatitis using woodchucks, chronically infected with the woodchuck hepatitis virus.
"
2.
Carcinogenesis
12/01/1986 - "
These results support the hypothesis that BHA inhibits AFB carcinogenesis via the induction of phase II biotransformation pathways such as glutathione S-transferase, which act to reduce the amount of AFB-epoxide available for binding to DNA.
"
3.
Hepatocellular Carcinoma (Hepatoma)
08/15/1996 - "
This protein is now referred to as rGSTA5 and is noteworthy because of its high activity towards aflatoxin B1-8,9-epoxide, its marked inducibility by chemoprotectors, its sex-specific regulation, and its over-expression in hepatoma and preneoplastic nodules.
"
4.
Hepatitis
11/14/1997 - "
In woodchuck hepatitis virus-positive woodchucks, activation of aflatoxin B1 to aflatoxin B1-8,9-epoxide was reduced when compared to woodchuck hepatitis virus-free animals, and the extent of the reduction was dependent on the severity of the hepatitis.
"
Related Drugs and Biologics
1.
Aflatoxin B1 (Aflatoxin B)
2.
Mycotoxins
3.
Proteins (Proteins, Gene)
4.
Glutathione Transferase (Glutathione S-Transferase)
5.
DNA (Deoxyribonucleic Acid)
6.
Butylated Hydroxyanisole (BHA)