methylurea

10/01/2020 - "In this preclinical study, chemo-induced rat mammary tumors were obtained after a single injection of N-nitroso-N-methylurea intraperitoneally in 46 prepubescent (age 38 ± 2 days) female rats. "
01/01/2013 - "The aims of the present study were to investigate the migration capacity of DMSCs in vitro, and in vivo in a preclinical model of mammary tumors induced by N-nitroso-N-methylurea (NMU). "
03/01/2002 - "These studies were extended into trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model. "
09/01/1996 - "In this study, we measured intrinsic (preexisting) mdr1a, -1b, and -2 gene expression in N-nitroso-N-methylurea-induced rat mammary tumors. "
06/01/1978 - "Experiments were conducted to study the tumor response of hamster tracheas to N-nitroso-N-methylurea. "

11/01/2010 - "This study examined the effect of alcohol exposure in utero on N-nitroso-N-methylurea (NMU)-induced mammary cancer risk during adulthood. "
07/01/2021 - "We used the N-nitroso-N-methylurea (NMU) induced breast cancer model in rats. "
01/01/2016 - "Fetal alcohol exposed and control Sprague Dawley rats were given a dose of N-Nitroso-N-methylurea (MNU) at postnatal day 50 to induce mammary cancer growth. "
01/01/2013 - "N-nitroso-N-methylurea was injected to induce mammary cancer in offspring. "
01/01/2012 - "N-nitroso-N-methylurea (NMU) induces breast cancer in rodents, particularly in rats. "

01/01/2003 - "The aim of this study was to evaluate the effect of restraint stress on N-nitroso-N-methylurea (NMU)-induced mammary carcinogenesis. "
11/01/1998 - "No susceptibility of colon tissue implanted into the glandular stomach of rats to N-nitroso-N-methylurea carcinogenesis."
11/01/1996 - "Alterations in H-ras1 promoter conformation during N-nitroso-N-methylurea-induced mammary carcinogenesis and pregnancy."
04/01/1996 - "Tumorigenesis of rat mammary epithelial cells by N-nitroso-N-methylurea in an in vitro system: characterization of the microtumors."
03/15/1994 - "Experimental and control groups were sacrificed at various time points between 5 and 11 months after dosing with N-nitroso-N-methylurea in order to visualize progressive stages of carcinogenesis of the dorsolateral prostate, the anterior prostate, and the seminal vesicle. "

08/19/1991 - "Although administration of a single dose of N-nitroso-N-methylurea (NMU) to young virgin rats induces a high rate of mammary carcinomas, precise histogenesis of the carcinomas has not been well characterized. "
11/01/1988 - "Assays with N--nitroso--N--methylurea--induced rat mammary carcinomas were negative for RT activity."
01/01/1986 - "In rats, almost 90% of the mammary carcinomas induced by a single dose of nitroso-methylurea (NMU) possess H-ras-1 oncogenes. "
12/15/1983 - "Each of nine mammary carcinomas induced by a single injection of nitroso-methylurea into 50-day-old Buf/N female rats, contained a transforming H-ras-1 gene. "
12/15/1983 - "Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations."

02/10/2023 - "In this study, we established N-Nitroso-N-methylurea (MNU)-induced GPL mice model and induced precancerous lesions of gastric cancer cells (MC), i.e. "
01/01/2020 - "Palliative Role of Aqueous Ginger Extract on N-Nitroso-N-Methylurea-Induced Gastric Cancer."
01/01/2017 - "At 6 weeks of age, 65 transgenic mice and 53 wild-type mice were given drinking water containing N-nitroso-N-methylurea (MNU) for 5 alternating weeks to induce gastric cancer. "
07/01/1995 - "Results showed in synthesis of N-methyl-N-nitrosourea (MNU) with precursors of methylurea (0.42 mmol/L) and sodium nitrite (25 mmol/L) in a condition simulating human stomach, pH of the reaction system played an important role in the synthesis, the amount of synthetic chemical maximized at a pH of 1-3 and almost no synthesis was found at pH of 5-7. A study on the ability to synthesize MNU catalyzed by bacteria isolated from the patients with stomach cancer living in a high-risk area showed its synthesis could be accelerated by Pseudomonas aeruginosa at pH of 6-7 with its catalyzing activity existed in heat liable component of living bacteria. "
04/21/2016 - "Administration of DNA-demethylating drug 5-aza-2'-deoxycytidine (5-aza-dC) reduced gastric cancer incidence by ~74% (P < 0.05) in N-nitroso-N-methylurea-treated mice. "