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dihydroxydiphenyl-pyridyl methane
Also Known As:
DDPM; bis(p-hydroxyphenyl)pyridyl-2-methane; deacetylbisacodyl; desacetyl-bisacodyl; desacetylbisacodyl; 4,4'-(2-pyridinylmethylene)bisphenol
Networked:
9
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Cresols: 9
Bisacodyl: 141
dihydroxydiphenyl-pyridyl methane: 9
Related Diseases
1.
Carcinogenesis
01/01/1981 - "
These results indicate that DDPM administration in the "post-initiation" stage inhibited liver, kidney and bladder carcinogenesis in rats.
"
01/01/1981 - "
The effects of 4,4' -diaminodiphenylmethane (DDPM) administration in the "post-initiation" stage of liver, kidney and bladder carcinogenesis were examined in male F344 rats.
"
02/01/1984 - "
4,4'-Diaminodiphenylmethane (4,4'-methylenedianiline) (DDPM) promoted the development of thyroid tumors in rats treated with a subeffective dose of N-bis(2-hydroxypropyl)nitrosamine (2,2'-dihydroxy-N-nitrosodipropylamine) (DHPN) for thyroid tumorigenesis.
"
05/01/1987 - "
The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet), 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) ( 0.06% in diet), diethylnitrosamine (DEN) (0.001% in drinking water) and N-ethyl-N-hydroxyethylnitrosamine (EHEN) (0.1% in drinking water), EHEN-induced oesophagus and kidney carcinogenesis and forestomach carcinogenesis induced by butylated hydroxyanisole (1.0% in diet) were examined in F344 male rats.
"
07/01/1986 - "
The antioxidants used were butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), sodium L-ascorbate, alpha-tocopherol, ethoxyquin and p,p'-diaminodiphenylmethane (DDPM), which is an inhibitor of carcinogenesis in the liver, kidney and urinary bladder.
"
2.
Hepatocellular Carcinoma (Hepatoma)
03/01/1984 - "
DDPM did not show clear effects on the development of liver cell carcinoma but enhanced the induction of cholangiofibromas, cholangiofibrosis and, very markedly, spongiosis hepatis.
"
01/01/1981 - "
The incidence of hepatocellular carcinoma was significantly less in rats given DDPM than in controls.
"
05/01/1987 - "
The incidences of hyperplastic nodules and hepatocellular carcinomas were significantly decreased in 2-AAF or 3'-Me-DAB + DDPM groups.
"
03/01/1986 - "
The incidence of hepatocellular carcinoma (HCC) was significantly decreased in the groups given ethoxyquin or DDPM.
"
3.
Neoplasms (Cancer)
02/01/1984 - "
No tumors were found in the kidneys and lungs of rats given DDPM alone and in those of control rats.
"
02/01/1984 - "
Untreated rats and rats given DDPM alone had no thyroid tumors after 20 weeks.
"
01/01/1981 - "
DDPM decreased the incidence and average number/cm2 of neoplastic nodules and renal cell tumors of the kidney.
"
01/01/1993 - "
DDPM, also a goitrogen, clearly inhibited the development of follicular cell tumors in the thyroid.
"
02/01/1984 - "
Incidences of kidney tumors were 38% (8/21) in rats given DHPN and then DDPM and 28% (6/21) in rats given DHPN alone.
"
4.
Body Weight (Weight, Body)
02/01/1984 - "
Male inbred W rats were given a single ip injection of 280 mg DHPN/100 g body weight and fed diets with or without 1,000 ppm DDPM.
"
07/01/1986 - "
Female Sprague-Dawley rats of 50 days old were treated with 2.5 mg/100 g body weight of DMBA, and from 1 week later were given diet supplemented with 1% BHA, 0.7% BHT, 5% sodium L-ascorbate, 1.5% alpha-tocopherol, 0.5% ethoxyquin or 0.1% DDPM for 33 weeks and then killed.
"
03/01/1986 - "
Rats were initially given a single ip injection of diethylnitrosamine (200 mg/kg body weight) and fed basal diet containing 0.02% 2-acetylaminofluorene from week 2 to week 8. Animals were subjected to partial hepatectomy at the end of week 3. From week 12 to week 36, they were given basal diet containing 2% BHA, 1% BHT, 0.8% ethoxyquin, 1% alpha-tocopherol, 0.1% DDPM, 1% acetaminophen, or 1% glutathione, then killed at week 40, 4 weeks after cessation of treatment with the test chemicals.
"
5.
Papilloma (Papillomatosis)
05/01/1987 - "
Development of papillomas in the oesophagus but not in tumours in the forestomach was also inhibited by DDPM.
"
01/01/1981 - "
DDPM inhibited the induction of papillomas in the bladder.
"
Related Drugs and Biologics
1.
Butylated Hydroxyanisole (BHA)
2.
4,4'-diaminodiphenylmethane
3.
alpha-Tocopherol
4.
2-Acetylaminofluorene (2 Acetylaminofluorene)
5.
Ethoxyquin
6.
Diethylnitrosamine (N-Nitrosodiethylamine)
7.
Butylated Hydroxytoluene (BHT)
8.
Drinking Water
9.
Antithyroid Agents (Antithyroid Drugs)
10.
Sodium
Related Therapies and Procedures
1.
Withholding Treatment
2.
Hepatectomy