intybin

has both antimalarial and neuroprotective activities

Also Known As:

lactucopicrin; lactucopicrin3,3a,4,5,9a,9b-hexahydro-4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methyleneazuleno(4,5-b)furan-2,7-dione p-hydroxyphenylacetate hydrate

Networked: 7 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - intybin: 7
- Lactones: 1549
  - intybin: 7

Experts

1.	Du, Yushi: 3 articles (01/2022 - 01/2021)
2.	Li, Qing: 3 articles (01/2022 - 01/2021)
3.	Liu, Xiuping: 3 articles (01/2022 - 01/2021)
4.	Wang, Dongliang: 3 articles (01/2022 - 01/2021)
5.	Ling, Wenhua: 2 articles (01/2022 - 01/2021)
6.	He, Luanying: 2 articles (01/2021 - 01/2021)
7.	Weng, Hui: 2 articles (01/2021 - 01/2021)
8.	Zheng, Jiakun: 2 articles (01/2021 - 01/2021)
9.	Chen, Guanyu: 1 article (01/2022)
10.	Xiang, Panyin: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "In the present study the anticancer effects of lactucopicrin against human skin SKMEL-5 cancer cell line were investigated. " 09/01/2019 - "Lactucopicrin exhibits significant antiproliferative effects on the osteosarcoma cells and may prove essential in the development of systemic therapy for this malignancy." 09/01/2019 - "Lactucopicrin, a sesquiterpene lactone, has been reported to exhibit anticancer activity against different cancer types. " 01/01/2021 - "Lactucopicrin, a bitter sesquiterpene lactone of leafy vegetables, such as chicory, curly escarole, and lettuce, possesses anti-malarial, anti-cancer and analgesic properties. "
2.	Atherosclerosis 01/01/2021 - "This study is focused on the impact of lactucopicrin on NF-κB activation in inflammed macrophages and atherogenesis in a mouse model of atherosclerosis. " 01/01/2021 - "Dietary lactucopicrin inhibits atherogenesis in mice likely by its anti-inflammatory property. " 01/01/2022 - "Terpene lactucopicrin, affluent in vegetables of the Asteraceae family (e.g., chicory, curly escarole, and lettuce) can inhibit atherogenesis in mice. " 01/01/2021 - "Lactucopicrin Inhibits Cytoplasmic Dynein-Mediated NF-κB Activation in Inflammated Macrophages and Alleviates Atherogenesis in Apolipoprotein E-Deficient Mice."
3.	Osteosarcoma (Osteogenic Sarcoma) 09/01/2019 - "In this study, the anticancer effect of Lactucopicrin was examined against human osteosarcoma cells along with its effects on cell migration and invasion, cell cycle phase distribution and Raf signalling pathway. " 09/01/2019 - "The human osteosarcoma cells Sao-2 were treated with various concentrations of Lactucopicrin for 24 h. " 09/01/2019 - "Growth inhibition of Saos-2 osteosarcoma cells by lactucopicrin is mediated via inhibition of cell migration and invasion, sub-G1 cell cycle disruption, apoptosis induction and Raf signalling pathway." 09/01/2019 - "Lactucopicrin exhibits significant antiproliferative effects on the osteosarcoma cells and may prove essential in the development of systemic therapy for this malignancy."
4.	Glioblastoma (Glioblastoma Multiforme) 12/10/2020 - "Implication of Lactucopicrin in Autophagy, Cell Cycle Arrest and Oxidative Stress to Inhibit U87Mg Glioblastoma Cell Growth." 12/10/2020 - "In this study, we propose lactucopicrin (LCTP), a natural sesquiterpene lactone from Lactucavirosa, as a molecule able to control the growth of glioblastoma continuous cell line U87Mg. "
5.	Atherosclerotic Plaque (Atheroma) 01/01/2022 - "Moreover, ApoE-/- mice fed a high fat diet supplemented with lactucopicrin for 12 weeks display fewer macrophage foam cells within atherosclerotic plaques relative to the control mice. "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Cytoplasmic Dyneins
4.	Neuroprotective Agents
5.	Terpenes (Terpenoids)
6.	Nerve Growth Factors (Neurotrophins)
7.	Apolipoproteins E (ApoE)
8.	Apolipoproteins
9.	Antimalarials (Antimalarial Agents)
10.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Therapeutics